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Wortmannin

(HB2778)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Wortmannin
Alternative names SL-2052
Purity >99%
Description Potent, selective, irreversible PI3-K inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (3) Frequently bought together
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Biological Data

Biological description Potent, selective, non-compettive and irreversible PI3-K inhibitor (IC50 = 2-4 nM). Also inhibits PI3-K related kinases and PLK1. Cell permeable. Shows variety of biological actions.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview DMSO (50mM) and Ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >99%
Chemical name (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-f uro[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6, 9-trione
Molecular Weight 428.44
Molecular Formula C23H24O8
CAS Number 19545-26-7
PubChem identifier 3003565
SMILES O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O
InChiKey QDLHCMPXEPAAMD-ZGSWIPFCSA-N

References for Wortmannin

References are publications that support the biological activity of the product

  • Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

    Liu et al (2005) Chem Biol 12(1) : 99-107
    Read more (PubMedID: 15664519)

  • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

    Ui et al (1995) Trends Biochem Sci 20(8) : 303-7
    Read more (PubMedID: 7667888)

  • Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

    Powis et al (1994) Cancer Res 54(9) : 2419-23
    Read more (PubMedID: 8162590)

3 Item(s)

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Grouped product items
Order: HB2778
Pack PriceQty
1mg
$76
5mg
$246
10mg
$455
Potent, selective, irreversible PI3-K inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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