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Wortmannin

(HB2778)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Wortmannin
Alternative names SL-2052
Purity >99%
Description Potent, selective, irreversible PI3-K inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (3) Frequently bought together
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Biological Data

Biological description Potent, selective, non-compettive and irreversible PI3-K inhibitor (IC50 = 2-4 nM). Also inhibits PI3-K related kinases and PLK1. Cell permeable. Shows variety of biological actions.

Solubility & Handling

Solubility overview DMSO (50mM) and Ethanol (5mM)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >99%
Chemical name (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-f uro[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6, 9-trione
Molecular Weight 428.44
Molecular Formula C23H24O8
CAS Number 19545-26-7
PubChem identifier 3003565
SMILES O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O
InChiKey QDLHCMPXEPAAMD-ZGSWIPFCSA-N

References for Wortmannin

References are publications that support the biological activity of the product

  • Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

    Liu et al (2005) Chem Biol 12(1) : 99-107
    Read more (PubMedID: 15664519)

  • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

    Ui et al (1995) Trends Biochem Sci 20(8) : 303-7
    Read more (PubMedID: 7667888)

  • Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

    Powis et al (1994) Cancer Res 54(9) : 2419-23
    Read more (PubMedID: 8162590)

3 Item(s)

Related Products
Grouped product items
Order: HB2778
Pack PriceQty
1mg
$79
5mg
$257
10mg
$475
Potent, selective, irreversible PI3-K inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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