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Biological Data Biological description Potent, selective, non-compettive and irreversible PI3-K inhibitor (IC50 = 2-4 nM). Also inhibits PI3-K related kinases and PLK1. Cell permeable. Shows variety of biological actions.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview DMSO (50mM) and Ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (1S ,6bR ,9aS ,11R ,11bR ) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H -f uro[4,3,2-de ]indeno[4,5,-h ]-2-h ]-2-benzopyran-3,6, 9-trione
Molecular Formula C23 H24 O8
PubChem identifier 3003565
SMILES O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O
InChiKey QDLHCMPXEPAAMD-ZGSWIPFCSA-N
References for Wortmannin References are publications that support the biological activity of the product
Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Liu et al (2005) Chem Biol 12(1) : 99-107 Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Ui et al (1995) Trends Biochem Sci 20(8) : 303-7 Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Powis et al (1994) Cancer Res 54(9) : 2419-23
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Potent, selective, irreversible PI3-K inhibitor