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Z-VAD-FMK product vial image | Hello Bio
Z-VAD-FMK product vial image | Hello Bio
Biological Data
| Biological description | Broad spectrum caspase inhibitor. Blocks apoptosis and activation of caspases during Fas-L induced apoptosis. Also Inhibits T-cell proliferation displaying immunosuppressive properties. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (20 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone |
| Chemical structure | ![Z-VAD-FMK [187389-52-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Z-VAD-FMK [187389-52-2]") |
| Molecular Formula | C22H30FN3O7 |
| PubChem identifier | 5497174 |
| SMILES | C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1 |
| InChiKey | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
References for Z-VAD-FMK
References are publications that support the biological activity of the product
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Radiation-induced cytochrome <i>c</i> release and the neuroprotective effects of the pan-caspase inhibitor z-VAD-fmk in the hypoglossal nucleus.
Li J et al (2014) Exp Ther Med 7(2) : 383-388. -
Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties.
Lawrence CP et al (2012) Toxicol Appl Pharmacol 265(1) : 103-12. -
Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes.
Mundle SD et al (1999) Cancer Lett 140(1-2) : 201-7. -
Inhibition of human caspases by peptide-based and macromolecular inhibitors.
Garcia-Calvo M et al (1998) J Biol Chem 273(49) : 32608-13.
Broad spectrum caspase inhibitor
![Z-VAD-FMK [187389-52-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1285.png "Z-VAD-FMK [187389-52-2]")
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