Histone deacetylase (HDAC)
Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.
Strontium chloride (HB3424)
Description:Calcium sensing receptor (CaSR) agonist. Induces MSC osteogenic differentiation.
-
SU 5402 (HB3133)
Description:Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Purity:>95%
-
T3 (HB7470)
Description:Thyroid hormone. Frequently used in various stem cell protocols.
Purity:>98%
-
Venlafaxine hydrochloride (HB1743)
Description:Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%
-
WHI-P 154 (HB1431)
Description:Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.
Purity:>99%
-
Wnt-C59 (HB3155)
Description:Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation.
Purity:>99%
-
XAV 939 (HB0660)
Description:Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.
Purity:>98%
-
ROCK inhibitor Y-27632 (HB2297)
Description:Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts.
Purity:>99%
-
Zebularine (HB1378)
Description:DNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.
Purity:>99%
