Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. 1  Review
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    Description:

    Calcium sensing receptor (CaSR) agonist. Induces MSC osteogenic differentiation.

    Pack:
    1g
    Price:
    $106
    Qty:
  2. SU 5402 (HB3133)

    Description:

    Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.

    Purity:

    >95%

    Pack:
    1mg
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    Pack:
    5mg
    Price:
    $144
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  3. Description:

    Thyroid hormone. Frequently used in various stem cell protocols.

    Purity:

    >98%

    Pack:
    50mg
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    Pack:
    100mg
    Price:
    $59
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    Pack:
    250mg
    Price:
    $145
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  4. Description:

    Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $76
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    Pack:
    50mg
    Price:
    $287
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  5. WHI-P 154 (HB1431)

    Description:

    Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $85
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    Pack:
    25mg
    Price:
    $307
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  6. Wnt-C59 (HB3155)

    Description:

    Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $271
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    Pack:
    50mg
    Price:
    $1,056
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  7. XAV 939 (HB0660)

    Description:

    Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $115
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    Pack:
    25mg
    Price:
    $257
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    Pack:
    50mg
    Price:
    $465
    Qty:
  8. 8  Reviews
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    Description:

    Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $46
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    Pack:
    2mg
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    Pack:
    5mg
    Price:
    $124
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    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    5x10mg
    Price:
    $786
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    Pack:
    25mg
    Price:
    $339
    Qty:
    Pack:
    50mg
    Price:
    $588
    Qty:
    Pack:
    10mM solution (in 1mL DMSO)
    Price:
    $180
    Qty:
    Pack:
    50mM (add 1ml water)
    Price:
    $426
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    Pack:
    100mM (add 1ml water)
    Price:
    $710
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  9. Zebularine (HB1378)

    Description:

    DNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $43
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    Pack:
    5mg
    Price:
    $92
    Qty:
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