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Biological Data Biological description Thyroid hormone with many biological actions. It is essential for embryogenesis and brain development, T3 increases neuronal differentiation.
It is frequently used as part of various stem cell related protocols:
Promotes neuronal differentiation of embryonic neural stem cells (eNSCs)
Beneficial for stem cell maintenance and promotes trophoblast differentiation and improves cell survival and passaging efficiency.
Used when generating hiPSC-cardiomyocytes (hiPSC-CM)
Aids generation of cortical spheroids from hPSCs and culture of 3D spheroids.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name O-(4-Hydroxy-3-iodophenyl-3,5-diiodo-L-tyrosine
Chemical structure
Molecular Formula C15 H12 I3 NO4
SMILES C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O
InChi InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChiKey AUYYCJSJGJYCDS-LBPRGKRZSA-N
References for T3 References are publications that support the biological activity of the product
Thyroid hormone enhances stem cell maintenance and promotes lineage-specific differentiation in human embryonic stem cells. Deng C et al (2022) Stem cell research & therapy 13 : 120 The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. Ma H et al (2022) Cell stem cell 29 : 795-809.e11 Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Parikh SS et al (2017) Circulation research 121 : 1323-1330 Thyroid hormone promotes neuronal differentiation of embryonic neural stem cells by inhibiting STAT3 signaling through TRα1. Chen C et al (2012) Stem cells and development 21 : 2667-81
Thyroid hormone. Frequently used in various stem cell protocols.
![T3 [6893-02-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb7470.png "T3 [6893-02-3]")
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