|Alternative names|| Thyroid hormone triiodothyronine (T3), |
Thyroid hormone. Frequently used in various stem cell protocols.
|Biological description|| |
Thyroid hormone with many biological actions. It is essential for embryogenesis and brain development, T3 increases neuronal differentiation.
It is frequently used as part of various stem cell related protocols:
- Promotes neuronal differentiation of embryonic neural stem cells (eNSCs)
- Beneficial for stem cell maintenance and promotes trophoblast differentiation and improves cell survival and passaging efficiency.
- Used when generating hiPSC-cardiomyocytes (hiPSC-CM)
- Aids generation of cortical spheroids from hPSCs and culture of 3D spheroids.
Solubility & Handling
|Storage instructions|| -20°C |
|Solubility overview|| Soluble in DMSO (50 mM) |
|Important|| This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
|Chemical name|| O-(4-Hydroxy-3-iodophenyl-3,5-diiodo-L-tyrosine |
|Chemical structure|| |
|Molecular Formula|| C15H12I3NO4 |
|SMILES|| C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O |
|InChi|| InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
|InChiKey|| AUYYCJSJGJYCDS-LBPRGKRZSA-N |
References for T3
References are publications that support the biological activity of the product
Thyroid hormone enhances stem cell maintenance and promotes lineage-specific differentiation in human embryonic stem cells.
Deng C et al (2022) Stem cell research & therapy 13 : 120
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H et al (2022) Cell stem cell 29 : 795-809.e11
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Parikh SS et al (2017) Circulation research 121 : 1323-1330
Thyroid hormone promotes neuronal differentiation of embryonic neural stem cells by inhibiting STAT3 signaling through TRα1.
Chen C et al (2012) Stem cells and development 21 : 2667-81