My Cart
My account
Menu
Main Menu

SU 5402

(HB3133)
Be the first to add a publication
Technical documents: Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name SU 5402
Purity >95%
Description Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
Write Your Own Review
You're reviewing:SU 5402
Rate this item:

Biological Data

Biological description Potent FGFR and VEGFR inhibitor (IC50 values are 0.02, 0.03, 0.51 and >100 µM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Attenuates integrin β4-induced neural stem cell differentiation. Shows potent in vitro and in vivo anticancer activity.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
Chemical name 2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl idene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
Molecular Weight 296.32
Chemical structure SU 5402 | [215543-92-3] Chemical Structure
Molecular Formula C17H16N2O3
CAS Number 215543-92-3
PubChem identifier 5289418
SMILES Cc1c[nH]c(c1CCC(=O)O)/C=C2/c3ccccc3NC2=O
InChi InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChiKey JNDVEAXZWJIOKB-JYRVWZFOSA-N
MDL number MFCD08235144
Appearance Light orange to dark orange

References for SU 5402

References are publications that support the biological activity of the product

  • Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.

    Buchholz et al (2013) Stem Cells Transl Med 2(5) : 384-93
    Read more (PubMedID: 23599499)

  • Neural stem cell differentiation is mediated by integrin beta4 in vitro.

    Su et al (2009) Int J Biochem Cell Biol 41(4) : 916-24
    Read more (PubMedID: 18834954)

  • Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.

    Sun et al (1999) J Med Chem 42(25) : 5120-30
    Read more (PubMedID: 10602697)

3 Item(s)

Related Products
Grouped product items
Order: HB3133
Pack PriceQty
1mg
$72
5mg
$138
Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

Pexidartinib (PLX3397)
HB8991

Potent CSF-1R inhibitor. Widely used microglia-depletion agent.

Related Products

LDN193189 hydrochloride (LDN)
Code:
HB5624
Pack:
10mg, 50mg
Price:
$176, $635
Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of...
ROCK inhibitor Y-27632
Code:
HB2297
Pack:
1mg, 2mg, 5mg, 10mg, 5x10mg, 25mg, 50mg, 10mM solution (in 1mL DMSO), 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$44, $69, $119, $168, $754, $325, $564, $172, $408, $680
(Free trial)

Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

SB 431542
Code:
HB3555
Pack:
1mg, 5mg, 2x5mg, 10mg, 25mg, 50mg, 10mM (1mL in DMSO)
Price:
$109, $153, $240, $233, $508, $959, $154
(Free trial)
Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation...