Product overview

Name SU 5402
Purity >95%
Description Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
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Biological Data

Biological description Potent FGFR and VEGFR inhibitor (IC50 values are 0.02, 0.03, 0.51 and >100 µM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Attenuates integrin β4-induced neural stem cell differentiation. Shows potent in vitro and in vivo anticancer activity.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name 2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl idene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
Molecular Weight 296.32
Chemical structure SU 5402 |  [215543-92-3] Chemical Structure
Molecular Formula C17H16N2O3
CAS Number 215543-92-3
PubChem identifier 5289418
SMILES Cc1c[nH]c(c1CCC(=O)O)/C=C2/c3ccccc3NC2=O
InChi InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
MDL number MFCD08235144
Appearance Light orange to dark orange

References for SU 5402

References are publications that support the biological activity of the product
  • Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.

    Buchholz et al (2013) Stem Cells Transl Med 2(5) : 384-93
  • Neural stem cell differentiation is mediated by integrin beta4 in vitro.

    Su et al (2009) Int J Biochem Cell Biol 41(4) : 916-24
  • Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.

    Sun et al (1999) J Med Chem 42(25) : 5120-30

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