Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Description:

    Serotonin/norepinephrine reuptake inhibitor (SNRI)

    Purity:

    >99%

    Pack:
    50mg
    Price:
    $517
    Qty:
  2. Xanthorrhizol (HB4127)

    Description:

    Potent COX-2 and iNOS inhibitor

    Purity:

    >97%

    Pack:
    1mg
    Price:
    $179
    Qty:
  3. Pack:
    10mg
    Price:
    $189
    Qty:
    Pack:
    50mg
    Price:
    $734
    Qty:
  4. XAV 939 (HB0660)

    Description:

    Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $115
    Qty:
    Pack:
    25mg
    Price:
    $257
    Qty:
    Pack:
    50mg
    Price:
    $465
    Qty:
  5. Pack:
    10mg
    Price:
    $141
    Qty:
    Pack:
    50mg
    Price:
    $589
    Qty:
  6. 9  Reviews
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    Description:

    Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $46
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5mg
    Price:
    $124
    Qty:
    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    5x10mg
    Price:
    $786
    Qty:
    Pack:
    25mg
    Price:
    $339
    Qty:
    Pack:
    50mg
    Price:
    $588
    Qty:
    Pack:
    10mM solution (in 1mL DMSO)
    Price:
    $180
    Qty:
    Pack:
    50mM (add 1ml water)
    Price:
    $426
    Qty:
    Pack:
    100mM (add 1ml water)
    Price:
    $710
    Qty:
  7. YM-254890 (HB6283)

    Description:

    Potent Gq/11 signaling inhibitor. Reported as Gq- G-protein inhibitor and broad-spectrum inhibitor for Gq- and Gs-proteins.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $439
    Qty:
  8. Pack:
    10mg
    Price:
    $216
    Qty:
    Pack:
    50mg
    Price:
    $858
    Qty:
  9. Description:

    Potent 5-HT3 antagonist and 5-HT4 agonist. Also selective IK1 channel agonist.

    Purity:

    >99%

    Pack:
    50mg
    Price:
    $621
    Qty:
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