Gq- G-protein inhibitor which potently inhibits Gq/11 heterotrimeric G protein signaling by blocking GDP exchange of GTP on the α- subunit of the Gq complex. Recently reported to act as a broad-spectrum inhibitor for Gq- and Gs-proteins and exhibits a biased inhibition on Gi/o signaling, without affecting non-GPCR-mediated cellular signaling (Peng et al 2021). Shown to attenuate ADP-, collagen-, TRAP-, arachidonic acid- and U46619-induced platelet aggregation to show antithrombotic effects.
Solubility & Handling
Solubility overview
Soluble in DMSO (10mg/ml)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Understanding purity and quality - a guide for life scientists
