XE 991 dihydrochloride

Technical documents: SDS CoA Datasheet

Product overview

Name XE 991 dihydrochloride
Purity >98%
Description Potent, selective Kv7 channel blocker
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Biological Data

Biological description

XE 991 dihydrochloride is a potent, selective and water soluble Kv7 (KCNQ) channel blocker.

XE 991 inhibits KCNQ type IM (M-current), Kv4.3 and Kv1.2 (IC50 values are 0.71, >43 and>100 µM) and blocks KCNQ1 current (Kd = 78 µM).

XE 991 also enhances ACh release (EC50 = 490 nM) and facilitates LTP (long term potentiation). Additionally, XE 991 shows cognitive enhancing actions.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
Molecular Weight 449.37
Chemical structure XE 991 dihydrochloride  [122955-42-4] Chemical Structure
Molecular Formula C26H20N2O.2HCl
CAS Number 122955-42-4
PubChem identifier 45073462
Source Synthetic
InChi InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H
MDL number MFCD05662331
Appearance Off-white solid

References for XE 991 dihydrochloride

References are publications that support the biological activity of the product
  • The M-current inhibitor XE991 decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease.

    Fontán-Lozano A et al (2011) Hippocampus 21(1) : 22-32.
  • Characterization of M-current in ventral tegmental area dop neurons.

    Koyama S et al (2006) J Neurophysiol 96(2) : 535-43.
  • Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.

    Wang HS et al (2000) Mol Pharmacol 57(6) : 1218-23.
  • Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.

    Zaczek R et al (1998) J Pharmacol Exp Ther 285(2) : 724-30.

4 Item(s)

These publications cite the use of XE 991 dihydrochloride purchased from Hello Bio:
  • Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons

    Canavier et al (2022) bioRxiv https://doi.org/10.1101/2021.10.26.465936 : doi
  • Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala

    Zhang H et al (2022) J Neurochem 161(6) : 478-491
    PubMedID: 35583089

2 Item(s)