XE 991 dihydrochloride product vial image | Hello Bio
XE 991 dihydrochloride product vial image | Hello Bio
Biological Data
Biological description
XE 991 dihydrochloride is a potent, selective and water soluble Kv7 (KCNQ) channel blocker.
XE 991 inhibits KCNQ type IM (M-current), Kv4.3 and Kv1.2 (IC50 values are 0.71, >43 and>100 µM) and blocks KCNQ1 current (Kd = 78 µM).
XE 991 also enhances ACh release (EC50 = 490 nM) and facilitates LTP (long term potentiation). Additionally, XE 991 shows cognitive enhancing actions.
Solubility & Handling
Solubility overview
Soluble in water (100mM)
Storage instructions
Room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The M-current inhibitor XE991 decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease.
Fontán-Lozano A et al (2011) Hippocampus 21(1) : 22-32.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek R et al (1998) J Pharmacol Exp Ther 285(2) : 724-30.
![XE 991 dihydrochloride [122955-42-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1090.png "XE 991 dihydrochloride [122955-42-4]")
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