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Images XE 991 dihydrochloride product vial image | Hello Bio
XE 991 dihydrochloride product vial image | Hello Bio Biological Data Biological description XE 991 dihydrochloride is a potent, selective and water soluble Kv 7 (KCNQ) channel blocker.
XE 991 inhibits KCNQ type IM (M-current), Kv 4.3 and Kv 1.2 (IC50 values are 0.71, >43 and>100 µM) and blocks KCNQ1 current (Kd = 78 µM).
XE 991 also enhances ACh release (EC50 = 490 nM) and facilitates LTP (long term potentiation). Additionally, XE 991 shows cognitive enhancing actions.
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 10,10-bis (4-Pyridinylmethyl)-9(10H )-anthracenone dihydrochloride
Chemical structure
Molecular Formula C26 H20 N2 O.2HCl
PubChem identifier 45073462
SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
InChi InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H
InChiKey WOGWMARIFDNZON-UHFFFAOYSA-N
Appearance Off-white solid
References for XE 991 dihydrochloride References are publications that support the biological activity of the product
The M-current inhibitor XE991 decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease. Fontán-Lozano A et al (2011) Hippocampus 21(1) : 22-32. Characterization of M-current in ventral tegmental area dop neurons. Koyama S et al (2006) J Neurophysiol 96(2) : 535-43. Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991. Wang HS et al (2000) Mol Pharmacol 57(6) : 1218-23. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. Zaczek R et al (1998) J Pharmacol Exp Ther 285(2) : 724-30.
Publications
These publications cite the use of XE 991 dihydrochloride purchased from Hello Bio:
Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons Canavier et al (2022) bioRxiv https://doi.org/10.1101/2021.10.26.465936 : doi
Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala Zhang H et al (2022) J Neurochem 161(6) : 478-491
Potent, selective Kv 7 channel blocker
![XE 991 dihydrochloride [122955-42-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1090.png "XE 991 dihydrochloride [122955-42-4]")
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