Product overview

Name (-)-Xestospongin C
Description Potent IP3 receptor inhibitor
Alternative names XeC
Write Your Own Review
You're reviewing:(-)-Xestospongin C
Rate this item:

Biological Data

Biological description Potent IP3 receptor inhibitor. Inhibits P3-mediated Ca2+ release (IC50 = 358 nM). Selective for IP3 receptors over ryanodine receptors. Inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase SERCA pump.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (2mM) or ethanol (2mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
Molecular Weight 446.71
Chemical structure (-)-Xestospongin C  [88903-69-9] Chemical Structure
Molecular Formula C28H50N2O2
CAS Number 88903-69-9
PubChem identifier 9846431
SMILES [H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2
InChiKey PQYOPBRFUUEHRC-HCKQMYSWSA-N

References for (-)-Xestospongin C

References are publications that support the biological activity of the product
  • Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse.

    Castonguay A et al (2002) Cell Calcium 32(1) : 39-47.
  • Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.

    De Smet P et al (1999) Cell Calcium 26(1-2) : 9-13.
  • Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.

    Gafni J et al (1997) Neuron 19(3) : 723-33.