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Biological Data
| Biological description | Potent IP3 receptor inhibitor. Inhibits P3-mediated Ca2+ release (IC50 = 358 nM). Selective for IP3 receptors over ryanodine receptors. Inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase SERCA pump. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (2mM) or ethanol (2mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine |
| Chemical structure | ![(-)-Xestospongin C [88903-69-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "(-)-Xestospongin C [88903-69-9]") |
| Molecular Formula | C28H50N2O2 |
| PubChem identifier | 9846431 |
| SMILES | [H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2 |
| InChiKey | PQYOPBRFUUEHRC-HCKQMYSWSA-N |
References for (-)-Xestospongin C
References are publications that support the biological activity of the product
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Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse.
Castonguay A et al (2002) Cell Calcium 32(1) : 39-47. -
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.
De Smet P et al (1999) Cell Calcium 26(1-2) : 9-13. -
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.
Gafni J et al (1997) Neuron 19(3) : 723-33.
Potent IP3 receptor inhibitor
![(-)-Xestospongin C [88903-69-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1241.png "(-)-Xestospongin C [88903-69-9]")
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