Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. GSK 429286 (HB2290)

    Description:

    Selective ROCK inhibitor

    Purity:

    >97%

    Pack:
    10mg
    Price:
    $270
    Qty:
  2. GSK'872 (HB5933)

    Description:

    Potent, selective RIP3 inhibitor. Necroptosis inhibitor.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $135
    Free trial
    Qty:
    Pack:
    50mg
    Price:
    $567
    Qty:
    Pack:
    10mM solution (in 1mL DMSO)
    Price:
    $88
    Qty:
  3. Pack:
    10mg
    Price:
    $283
    Qty:
    Pack:
    50mg
    Price:
    $1,086
    Qty:
  4. Pack:
    10mg
    Price:
    $282
    Qty:
    Pack:
    50mg
    Price:
    $1,096
    Qty:
  5. GsMTx4 (HB1161)

    Description:

    Piezo and TRP mechanosensitive channels inhibitor

    Purity:

    >95%

    Pack:
    100μg
    Price:
    $270
    Qty:
  6. Description:

    Antibody to the GST tag - widely used as a protein tag in molecular biology. Part of the ValidAb™ range of highly validated, data-rich antibodies. 

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Species Independent
    Pack:
    25μg
    Price:
    $141
    Qty:
    Pack:
    100μg
    Price:
    $315
    Qty:
  7. GV-58 (HB3920)

    Description:

    Selective N- and P/Q-type Ca2+-channel agonist

    Purity:

    >97%

    Pack:
    5mg
    Price:
    $304
    Qty:
  8. Pack:
    25mg
    Price:
    $659
    Qty:
  9. Pack:
    10mg
    Price:
    $112
    Qty:
    Pack:
    50mg
    Price:
    $462
    Qty:
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    Description:

    Non-competitive AMPA receptor antagonist. Also blocks kainate GluK3 homomeric receptors.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $165
    Qty:
    Pack:
    50mg
    Price:
    $694
    Qty:
    Pack:
    10mM (add 1ml water)
    Price:
    $108
    Qty:
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