Product overview

Name GsMTx4
Description Piezo and TRP mechanosensitive channels inhibitor
Alternative names M-TRTx-Gr1a, M-theraphotoxin-Gr1a
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Biological Data

Biological description

Gating modifier peptide from spider venom which selectively inhibits mechanosensitive ion channels such as Piezo and TRP.

It is commonly used in the study mechanosensitive channels function in physiology and pathology.

It has also recently been reported to inhibit a stretch-activated BK channel (SAKcaC) and TACAN, a mechanosensitive ion channel involved in pain regulation.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name H-Gly-DL-Cys(1)-DL-Leu-DL-Glu-DL-Phe-DL-Trp-DL-Trp-DL-Lys-DL-Cys(2)-DL-Asn-DL-Pro-DL-Asn-DL-Asp-DL-Asp-DL-Lys-DL-Cys(3)-DL-Cys(1)-DL-Arg-DL-Pro-DL-Lys-DL-Leu-DL-Lys-DL-Cys(2)-DL-Ser-DL-Lys-DL-Leu-DL-Phe-DL-Lys-DL-Leu-DL-Cys(3)-DL-Asn-DL-Phe-DL-Ser-DL-Phe-NH2
Molecular Weight 4095.86
Molecular Formula C185H273N49O45S6
CAS Number 1209500-46-8
PubChem identifier 90488987
SMILES [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
InChiKey WVDNTWXIIKNMHY-UHFFFAOYSA-N

References for GsMTx4

References are publications that support the biological activity of the product
  • TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

    Beaulieu-Laroche et al (2020) Cell. 180(5) : 956-967
  • The Neuropeptide GsMTx4 Inhibits a Mechanosensitive BK Channel Through the Voltage-Dependent Modification Specific to Mechano-Gating

    Li et al (2019) J Biol Chem. 294(31) : 11892-11909
  • GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels

    Gnanasambandam et al (2017) Biophys J. 112(1) : 31-45.
  • Human PIEZO1: removing inactivation.

    Bae C et al (2013) Biophys J 105(4) : 880-6.
  • A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain.

    Park SP et al (2008) Pain 137(1) : 208-17.