Product overview
| Name | GsMTx4 |
| Description | Piezo and TRP mechanosensitive channels inhibitor |
| Alternative names | M-TRTx-Gr1a, M-theraphotoxin-Gr1a |
Write Your Own Review
Biological Data
| Biological description | Gating modifier peptide from spider venom which selectively inhibits mechanosensitive ion channels such as Piezo and TRP. It is commonly used in the study mechanosensitive channels function in physiology and pathology. It has also recently been reported to inhibit a stretch-activated BK channel (SAKcaC) and TACAN, a mechanosensitive ion channel involved in pain regulation. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in water (1mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | H-Gly-DL-Cys(1)-DL-Leu-DL-Glu-DL-Phe-DL-Trp-DL-Trp-DL-Lys-DL-Cys(2)-DL-Asn-DL-Pro-DL-Asn-DL-Asp-DL-Asp-DL-Lys-DL-Cys(3)-DL-Cys(1)-DL-Arg-DL-Pro-DL-Lys-DL-Leu-DL-Lys-DL-Cys(2)-DL-Ser-DL-Lys-DL-Leu-DL-Phe-DL-Lys-DL-Leu-DL-Cys(3)-DL-Asn-DL-Phe-DL-Ser-DL-Phe-NH2 |
| Molecular Weight | 4095.86 |
| Molecular Formula | C185H273N49O45S6 |
| CAS Number | 1209500-46-8 |
| PubChem identifier | 90488987 |
| SMILES | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
| InChiKey | WVDNTWXIIKNMHY-UHFFFAOYSA-N |
References for GsMTx4
References are publications that support the biological activity of the product
-
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
Beaulieu-Laroche et al (2020) Cell. 180(5) : 956-967 -
The Neuropeptide GsMTx4 Inhibits a Mechanosensitive BK Channel Through the Voltage-Dependent Modification Specific to Mechano-Gating
Li et al (2019) J Biol Chem. 294(31) : 11892-11909 -
GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels
Gnanasambandam et al (2017) Biophys J. 112(1) : 31-45. -
Human PIEZO1: removing inactivation.
Bae C et al (2013) Biophys J 105(4) : 880-6. -
A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain.
Park SP et al (2008) Pain 137(1) : 208-17.
Technical guides
Understanding purity and quality - a guide for life scientistsRelated Products
