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Biological Data Biological description Gating modifier peptide from spider venom which selectively inhibits mechanosensitive ion channels such as Piezo and TRP.
It is commonly used in the study mechanosensitive channels function in physiology and pathology.
It has also recently been reported to inhibit a stretch-activated BK channel (SAKcaC) and TACAN, a mechanosensitive ion channel involved in pain regulation.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name H-Gly-DL-Cys(1)-DL-Leu-DL-Glu-DL-Phe-DL-Trp-DL-Trp-DL-Lys-DL-Cys(2)-DL-Asn-DL-Pro-DL-Asn-DL-Asp-DL-Asp-DL-Lys-DL-Cys(3)-DL-Cys(1)-DL-Arg-DL-Pro-DL-Lys-DL-Leu-DL-Lys-DL-Cys(2)-DL-Ser-DL-Lys-DL-Leu-DL-Phe-DL-Lys-DL-Leu-DL-Cys(3)-DL-Asn-DL-Phe-DL-Ser-DL-Phe-NH2
Molecular Formula C185 H273 N49 O45 S6
PubChem identifier 90488987
SMILES [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
InChiKey WVDNTWXIIKNMHY-UHFFFAOYSA-N
References for GsMTx4 References are publications that support the biological activity of the product
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain Beaulieu-Laroche et al (2020) Cell. 180(5) : 956-967 The Neuropeptide GsMTx4 Inhibits a Mechanosensitive BK Channel Through the Voltage-Dependent Modification Specific to Mechano-Gating Li et al (2019) J Biol Chem. 294(31) : 11892-11909 GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Gnanasambandam et al (2017) Biophys J. 112(1) : 31-45. Human PIEZO1: removing inactivation. Bae C et al (2013) Biophys J 105(4) : 880-6. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Park SP et al (2008) Pain 137(1) : 208-17.
Piezo and TRP mechanosensitive channels inhibitor
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