Potent and selective RIP3 inhibitor. Binds to the RIP3 kinase domain (IC50 = 1.3 nM) and inhibits kinase activity with an IC50 of 1.3 nM. Demonstrates >1000-fold selectivity for RIP3 compared with >300 different kinases. Inhibits necroptosis, TLR3-, TNF-α- and virus-induced necrosis. Also induces caspase8-mediated apoptosis in a concentration-dependent manner (at higher concentration such as 3-10 µM).
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM), and in ethanol (100 mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Understanding purity and quality - a guide for life scientists
