Potent and selective RIP3 inhibitor. Binds to the RIP3 kinase domain (IC50 = 1.3 nM) and inhibits kinase activity with an IC50 of 1.3 nM. Demonstrates >1000-fold selectivity for RIP3 compared with >300 different kinases. Inhibits necroptosis, TLR3-, TNF-α- and virus-induced necrosis. Also induces caspase8-mediated apoptosis in a concentration-dependent manner (at higher concentration such as 3-10 µM).
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100 mM), and in ethanol (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Understanding purity and quality - a guide for life scientists
