Product overview

Name GSK J1
Description Potent, selective histone demethylase KDM6 subfamily inhibitor
Alternative names GSK-J1
Purity >99%
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Biological Data

Biological description Potent and selective histone demethylase KDM6 subfamily inhibitor, selective for JMJD3 and UTX (IC50 = 60 nM for human JMJD3). Reduces macrophage proinflammatory cytokine production.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetra hydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanin e
Molecular Weight 389.45
Chemical structure GSK J1  [1373422-53-7] Chemical Structure
Molecular Formula C22H23N5O2
CAS Number 1373422-53-7
PubChem identifier 56963315
SMILES O=C(CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O
InChiKey AVZCPICCWKMZDT-UHFFFAOYSA-N

References for GSK J1

References are publications that support the biological activity of the product
  • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

    Kruidenier L et al (2012) Nature 488(7411) : 404-8.