GYKI 53655 hydrochloride product vial image | Hello Bio
GYKI 53655 hydrochloride product vial image | Hello Bio
Biological Data
Biological description
Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466.
GYKI 53655 acts via an allosteric site at the AMPAR and inhibits channel gating downstream of glutamate binding.
The compound inhibits AMPA - mediated response in cells expressing human GluR1(GluA1) and GluR4(GluA4) (IC50 values are 6 µM and 5 µM for GluA1 and GluA4 subunits respectively).
At higher concentrations, GYKI 53655 also blocks kainate GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM).
Active in vivo. Shows anticonvulsive and neuroprotective effects.
Solubility & Handling
Solubility overview
Soluble in water (100mM, gentle warming) and in DMSO (100 mM)
Storage instructions
Room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![GYKI 53655 [143692-18-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0312_2.png "GYKI 53655 [143692-18-6]")
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