Product overview

Name GV-58
Purity >97%
Description Selective N- and P/Q-type Ca2+-channel agonist
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Biological Data

Biological description Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >97%
Chemical name (2R)-2-[[6-[[(5-Methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-1-butanol
Molecular Weight 374.5
Chemical structure GV-58 Chemical Structure
Molecular Formula C18H26N6OS
CAS Number 1402821-41-3
InChiKey DPTXJOUVBMUSGY-CYBMUJFWSA-N
Appearance White to off-white solid

References for GV-58

References are publications that support the biological activity of the product
  • Potentiation of neuromuscular transmission by a small molecule calcium channel gating modifier improves motor function in a severe spinal muscular atrophy mouse model.

    Ojala KS et al (2023) Human molecular genetics 32 : 1901-1911
  • Activation of Voltage-Gated Na(+) Current by GV-58, a Known Activator of Ca(V) Channels.

    Cho HY et al (2022) Biomedicines 10 :
  • Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome.

    Tarr TB et al (2013) The Journal of neuroscience : the official journal of the Society for Neuroscience 33 : 10559-67

3 Item(s)