ROCK (Rho-kinase)

Selective Hsp90 inhibitor. Also protects neuroprogenitor cells against apoptosis.

Potent, selective CXCR4 antagonist. Mobilizes hematopoietic stem cells.

Potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.

Leukemia stem cell activity inhibitor

Smo and hedgehog (Hh) signaling inhibitor. Also depletes stem like cancer cells and induces hESCs into endocrine cells.

Cyclooxygenase inhibitor. Regulates prostate stem cell antigen.

GLI1 antagonist. Hedgehog signaling inhibitor.

GLI antagonist. Also Hedgehog (Hh) signaling inhibitor.

Selective Hsp90 inhibitor. Breast cancer stem cell inhibitor.

Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.