Product overview

Name IWP 2
Purity >98%
Description Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.
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IWP 2 product vial image | Hello Bio

Biological Data

Biological description

Potent Wnt pathway inhibitor (IC50 = 27 nM) and PORCN inhibitor.

It also inhibits Dishevelled-2 (Dvl2- a Wnt-Fz signalling component) and LRP5/6 phosphorylation without inducing axin stability.

It blocks phagocytosis and secretion of pro-inflammatory cytokines.

Additionally, it suppresses R1 ESC self-renewal and may be used in the production of cardiac organoids.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name N-(6-Methyl-2-benzothiazolyl)-2-[(3 ,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Molecular Weight 466.6
Chemical structure IWP 2  [686770-61-6] Chemical Structure
Molecular Formula C22H18N4O2S3
CAS Number 686770-61-6
PubChem identifier 2155128

References for IWP 2

References are publications that support the biological activity of the product
  • Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells.

    Richards MH et al (2014) PLoS One 9(3) : e92159.
  • Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.

    Dawes LJ et al (2013) Invest Ophthalmol Vis Sci 54(3) : 1582-90.
  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

    Chen B et al (2009) Nat Chem Biol 5(2) : 100-7.

3 Item(s)

These publications cite the use of IWP 2 purchased from Hello Bio:
  • Un modèle alvéolaire basé sur le développement des nouveaux dispositifs et des nouveaux protocoles pour la différenciation des cellules souches pluripotentes humaines induites

    Hong Ye (2020) Thesis
  • An automatic cell culture platform for differentiation of human induced pluripotent stem cells

    Pitingolo et al (2020) Microelectronic Engineering : 111371

2 Item(s)