Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Additionally inhibits hedgehog (Hh) signaling pathway, downstream of SMO and SUFU. Displays antiproliferative, antitumor and apoptosis inducing activity. Also inhibits pluripotency maintaining factors c-Myc, Nanog, Oct4, Sox-2 in pancreatic cancer stem cells.
Solubility & Handling
Storage instructions
+4°C
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![GANT61 | NSC 136476 [500579-04-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3394.png "GANT61 | NSC 136476 [500579-04-4]")
Understanding purity and quality - a guide for life scientists
