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Images BIO product vial image | Hello Bio
BIO product vial image | Hello Bio Biological Data Biological description Potent GSK-3α/β inhibitor (IC50 = 5 nM). Exhibits reduced activity at CDK1/cyclin B, CDK2/cyclinA, CDK4/cyclin D1, CDK5/p35, MAPKK andPKC-subunit α (IC50 values are 0.32, 0.30, 10, 0.08, 10 and 12 μM respectively). Induces β-catenin stabilisation and protects hippocampal neurons from Aβ oligomer damage. Also inhibits Tyr276/216 phosphorylation and reduces β-catenin phosphorylation. Cell permeable. Maintains embryonic stem cell self-renewal and pluripotency and displays proliferation enhancing properties.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (10mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2'Z ,3'E )-6-Bromoindirubin-3'-oxime
Chemical structure
Molecular Formula C16 H10 BrN3 O2
PubChem identifier 448949
SMILES O/N=C(C1=CC=CC=C1N2)/C2=C3/C(NC4=C3C=CC(Br)=C4)=O
InChi InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
InChiKey WNWSUJQVZJJGLF-SQFISAMPSA-N
References for BIO References are publications that support the biological activity of the product
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Silva-Alvarez C et al (2013) Front Cell Neurosci 7 : 97 The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Tseng AS et al (2006) Chem Biol 13(9) : 957-63. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Meijer L et al (2003) Chem Biol 10(12) : 1255-66.
Potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.
![BIO [667463-62-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1259.png "BIO [667463-62-9]")
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