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Images BIO product vial image | Hello Bio
BIO product vial image | Hello Bio Biological Data Biological description Potent GSK-3α/β inhibitor (IC50 = 5 nM). Exhibits reduced activity at CDK1/cyclin B, CDK2/cyclinA, CDK4/cyclin D1, CDK5/p35, MAPKK andPKC-subunit α (IC50 values are 0.32, 0.30, 10, 0.08, 10 and 12 μM respectively). Induces β-catenin stabilisation and protects hippocampal neurons from Aβ oligomer damage. Also inhibits Tyr276/216 phosphorylation and reduces β-catenin phosphorylation. Cell permeable. Maintains embryonic stem cell self-renewal and pluripotency and displays proliferation enhancing properties.
Solubility & Handling Solubility overview Soluble in DMSO (10mM) or ethanol (10mM)
Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2'Z ,3'E )-6-Bromoindirubin-3'-oxime
Chemical structure
Molecular Formula C16 H10 BrN3 O2
PubChem identifier 448949
SMILES O/N=C(C1=CC=CC=C1N2)/C2=C3/C(NC4=C3C=CC(Br)=C4)=O
InChi InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
InChiKey WNWSUJQVZJJGLF-SQFISAMPSA-N
References for BIO References are publications that support the biological activity of the product
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Silva-Alvarez C et al (2013) Front Cell Neurosci 7 : 97 The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Tseng AS et al (2006) Chem Biol 13(9) : 957-63. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Meijer L et al (2003) Chem Biol 10(12) : 1255-66.
Potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.
![BIO [667463-62-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1259.png "BIO [667463-62-9]")
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