Product overview

Name BIO
Alternative names 6-BIO; 6BIO
Purity >98%
Description Potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.
Write Your Own Review
You're reviewing:BIO
Rate this item:


BIO product vial image | Hello Bio

Biological Data

Biological description Potent GSK-3α/β inhibitor (IC50 = 5 nM). Exhibits reduced activity at CDK1/cyclin B, CDK2/cyclinA, CDK4/cyclin D1, CDK5/p35, MAPKK andPKC-subunit α (IC50 values are 0.32, 0.30, 10, 0.08, 10 and 12 μM respectively). Induces β-catenin stabilisation and protects hippocampal neurons from Aβ oligomer damage. Also inhibits Tyr276/216 phosphorylation and reduces β-catenin phosphorylation. Cell permeable. Maintains embryonic stem cell self-renewal and pluripotency and displays proliferation enhancing properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (10mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Purity >98%
Chemical name (2'Z,3'E)-6-Bromoindirubin-3'-oxime
Molecular Weight 356.17
Chemical structure BIO  [667463-62-9] Chemical Structure
Molecular Formula C16H10BrN3O2
CAS Number 667463-62-9
PubChem identifier 448949
SMILES O/N=C(C1=CC=CC=C1N2)/C2=C3/C(NC4=C3C=CC(Br)=C4)=O
InChi InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
MDL number MFCD08705318
Appearance Red solid

References for BIO

References are publications that support the biological activity of the product
  • Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics.

    Silva-Alvarez C et al (2013) Front Cell Neurosci 7 : 97
  • The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes.

    Tseng AS et al (2006) Chem Biol 13(9) : 957-63.
  • GSK-3-selective inhibitors derived from Tyrian purple indirubins.

    Meijer L et al (2003) Chem Biol 10(12) : 1255-66.

3 Item(s)