Product overview

Name GANT 58
Description GLI1 antagonist. Hedgehog signaling inhibitor.
Purity >99%
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Biological Data

Biological description GLI1 antagonist. Hedgehog (Hh) signaling inhibitor (IC50 = 5 μM for inhibition of Hh signaling downstream of Smo and Sufu at the level of Gli). Induces apoptosis.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (25mM) or ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 2,3,4,5-Tetra(4-pyridyl)thiophene
Molecular Weight 392.48
Chemical structure GANT 58 |  [64048-12-0] Chemical Structure
Molecular Formula C24H16N4S
CAS Number 64048-12-0
PubChem identifier 253078
SMILES C1(C5=CC=NC=C5)=C(C3=CC=NC=C3)C(C2=CC=NC=C2)=C(C4=CC=NC=C4)S1
InChiKey USWLOKMMUTWFMD-UHFFFAOYSA-N

References for GANT 58

References are publications that support the biological activity of the product
  • Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells.

    Hou et al (50-9) Biochimie 2014 : 101
  • Small-molecule modulators of the Sonic Hedgehog signaling pathway.

    Stanton and Peng (2010) Mol Biosyst 6(1) : 44-54
  • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

    Lauth et al (2007) Proc Natl Acad Sci U S A 104(20) : 8455-60