Cytokine Storm / Immune response signaling

Cytokine storm describes an excessive immune response to external stimuli with the release of a large amount of pro-inflammatory cytokines. Cytokine storms occur in a range of infections and non-infectious diseases including COVID-19. The cytokine storm involves a variety of immune-related molecules such as interferon, interleukins, chemokines, CSFs and TNF-α. Increase in proinflammatory cytokines results in an influx of immune cells such as macrophages, T-Cells and neutrophils. The immune response to SARS-CoV2 infection also involves various signaling pathways. Researchers can save up to 50% on small molecules that affect cytokine storm and the immune response, as they are up to half the price of other suppliers.

View products: Angiotensin related | Cytokines, chemokines & NF-κB/I-κB | Inflammasomes | JAK/STAT | MAPK Signaling | PI3K/Akt/mTOR | Protease-Activated Receptors | TLR signaling

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  1. Rapamycin (HB2779)

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    Description:

    mTOR inhibitor and potent immunosuppressant. Also used in inducible gene editing methods (e.g. CRISPR/Cas9) and promotes hPSC differentiation.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $140
    Free trial
    Qty:
    Pack:
    5mg
    Price:
    $237
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  2. RWJ 67657 (HB1300)

    Description:

    Potent p38 MAPK inhibitor

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $56
    Qty:
    Pack:
    5mg
    Price:
    $94
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    Pack:
    10mg
    Price:
    $180
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  3. S14161 (HB4068)

    Description:

    pan Class I PI3K isoforms inhibitor

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $356
    Qty:
  4. SB 202190 (HB1301)

    Description:

    Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.

    Purity:

    >99%

    Pack:
    5mg
    Price:
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    Pack:
    10mg
    Price:
    $131
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    Pack:
    25mg
    Price:
    $325
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    Pack:
    50mg
    Price:
    $547
    Qty:
  5. SB 203580 (HB1302)

    Description:

    Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.

    Purity:

    >98%

    Pack:
    500μg
    Price:
    $45
    Qty:
    Pack:
    1mg
    Price:
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    Pack:
    10mg
    Price:
    $183
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    Pack:
    50mg
    Price:
    $674
    Qty:
  6. Pack:
    5mg
    Price:
    $56
    Qty:
    Pack:
    10mg
    Price:
    $89
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    Pack:
    25mg
    Price:
    $183
    Qty:
  7. Pack:
    1mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $163
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    Pack:
    50mg
    Price:
    $690
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  8. SP600125 (HB2234)

    Description:

    Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    Qty:
    Pack:
    50mg
    Price:
    $310
    Qty:
  9. Stattic (HB1437)

    Description:

    Selective STAT3 inhibitor

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $63
    Qty:
    Pack:
    25mg
    Price:
    $254
    Qty:
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