Product overview

Biological description


SLIGRL-NH2 is a PAR2 peptide agonist which is specific for activation of PAR2 over PAR1 and PAR4 (EC50 = 0.5-2.0µM).

The peptide is derived from the N-terminus of the rat PAR2 receptor sequence.


SLIGRL-NH2 is an itch-inducing agent which is commonly used to study histamine-independent itch. It evokes dose dependent scratching behaviour in mice. Interestingly, in pruritogen-responsive neurons that transmit the itch signal induced by SLIGRL-NH2, sex-related differences may exist.

The peptide has also been shown to enhance gastrointestinal transit in mice and rats

Active in vivo.

Purity >95%
Description PAR2 peptide agonist
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name SLIGRL (modifications: C-terminal amide)
Molecular Weight 656.82
Chemical structure SLIGRL-NH2 | [171436-38-7 ] Chemical Structure
Molecular Formula C29H56N10O7
Sequence (one letter) SLIGRL
Modifications C-terminal amide
CAS Number 171436-38-7
PubChem identifier 9831050
SMILES CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N
MDL number MFCD03093421

References for SLIGRL-NH2

References are publications that support the biological activity of the product
  • Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism.

    Zhang et al (30122898) Drug Des Devel Ther. 12 : 2403-2411
  • Sex-related differences in SLIGRL-induced pruritus in mice.

    Yamaura et al (2014) Life Sci. 94(1) : 54-7
  • The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo.

    Flynn et al (2011) J Biol Chem 286(21) : 19076-88
  • The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.

    Liu et al (2011) Sci Signal. 4(181) : 45
  • Protease-activated receptor-1 (PAR1) and PAR2 but not PAR4 mediate relaxations in lower esophageal sphincter.

    Huang et al (2007) Regul Pept. 142(1-2) : 37-43

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