SLIGRL-NH2 is a PAR2 peptide agonist which is specific for activation of PAR2 over PAR1 and PAR4 (EC50 = 0.5-2.0µM).
The peptide is derived from the N-terminus of the rat PAR2 receptor sequence.
Uses
SLIGRL-NH2 is an itch-inducing agent which is commonly used to study histamine-independent itch. It evokes dose dependent scratching behaviour in mice. Interestingly, in pruritogen-responsive neurons that transmit the itch signal induced by SLIGRL-NH2, sex-related differences may exist.
The peptide has also been shown to enhance gastrointestinal transit in mice and rats
References are publications that support the biological activity of the product
Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism.
Zhang et al (30122898) Drug Des Devel Ther. 12 : 2403-2411
Sex-related differences in SLIGRL-induced pruritus in mice.
The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo.
![SLIGRL-NH2 | [171436-38-7 ] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2920_1.png "SLIGRL-NH2 | [171436-38-7 ]")
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