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Biological Data

Biological description Selective STAT3 inhibitor. Inhibits STAT3 activation, dimerization and nuclear translocation. Enhances ROS formation. Shows apoptotic and anti-cancer actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 6-Nitrobenzo[b]thiophene 1,1-dioxide
Molecular Weight 211.19
Chemical structure Stattic  [19983-44-9] Chemical Structure
Molecular Formula C8H5NO4S
CAS Number 19983-44-9
PubChem identifier 2779853
SMILES C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
InChi InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
MDL number MFCD00173799

References for Stattic

References are publications that support the biological activity of the product
  • Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma.

    Pan Y et al (2013) PLoS One 8(1) : e54565.
  • The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation.

    Boengler K et al (2013) Curr Pharm Des 19(39) : 6890-5.
  • Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

    Schust J et al (2006) Chem Biol 13(11) : 1235-42.

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