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Biological Data
| Biological description | Selective STAT3 inhibitor. Inhibits STAT3 activation, dimerization and nuclear translocation. Enhances ROS formation. Shows apoptotic and anti-cancer actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 6-Nitrobenzo[b]thiophene 1,1-dioxide |
| Chemical structure | ![Stattic [19983-44-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Stattic [19983-44-9]") |
| Molecular Formula | C8H5NO4S |
| PubChem identifier | 2779853 |
| SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |
| InChi | InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
| InChiKey | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
References for Stattic
References are publications that support the biological activity of the product
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Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma.
Pan Y et al (2013) PLoS One 8(1) : e54565. -
The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation.
Boengler K et al (2013) Curr Pharm Des 19(39) : 6890-5. -
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
Schust J et al (2006) Chem Biol 13(11) : 1235-42.
Selective STAT3 inhibitor
![Stattic [19983-44-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1437.png "Stattic [19983-44-9]")
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