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SB 203580

(HB1302)
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Product overview

Name SB 203580
Purity >98%
Description Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4) Frequently bought together
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Biological Data

Biological description Potent and selective p38 MAPK inhibitor (IC50 values are 32.6 and 22.4 nM for active and inactive forms of p38 respectively). Exhibits higher selectivity for p38α over p38β (IC50 values are 50 and 500 nM respectively). Inhibits many kinases including tyrosine kinases p56 lck and c-src (IC50 = 5 µM) and also TNFα, IL-6, COX-1, COX-2. Also stimulates neural stem cell proliferation. Displays anti-inflammatory properties.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (25mM) or HCl (100mM, 1eq. HCl)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
Molecular Weight 377.44
Chemical structure SB 203580 [152121-47-6] Chemical Structure
Molecular Formula C21H16FN3OS
CAS Number 152121-47-6
PubChem identifier 176155
SMILES CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
InChiKey CDMGBJANTYXAIV-UHFFFAOYSA-N

References for SB 203580

References are publications that support the biological activity of the product

  • Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle.

    Munoz L et al (2010) Eur J Pharmacol 635(1-3) : 212-8.
    Read more (PubMedID: 20226180)

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    Read more (PubMedID: 10998351)

  • RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

    Wadsworth SA et al (1999) J Pharmacol Exp Ther 291(2) : 680-7.
    Read more (PubMedID: 10525088)

  • Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase.

    Börsch-Haubold AG et al (1998) J Biol Chem 273(44) : 28766-72.
    Read more (PubMedID: 9786874)

4 Item(s)

Related Products
Grouped product items
Order: HB1302
Pack PriceQty
500μg
$45
1mg
$81
10mg
$183
50mg
$674
Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
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