Potent and selective p38 MAPK inhibitor (IC50 values are 32.6 and 22.4 nM for active and inactive forms of p38 respectively). Exhibits higher selectivity for p38α over p38β (IC50 values are 50 and 500 nM respectively). Inhibits many kinases including tyrosine kinases p56 lck and c-src (IC50 = 5 µM) and also TNFα, IL-6, COX-1, COX-2. Also stimulates neural stem cell proliferation. Displays anti-inflammatory properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (25mM) or HCl (100mM, 1eq. HCl)
Storage instructions
+4°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![SB 203580 [152121-47-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1302.png "SB 203580 [152121-47-6]")
Understanding purity and quality - a guide for life scientists
