Potent and selective p38 MAPK inhibitor (IC50 values are 32.6 and 22.4 nM for active and inactive forms of p38 respectively). Exhibits higher selectivity for p38α over p38β (IC50 values are 50 and 500 nM respectively). Inhibits many kinases including tyrosine kinases p56 lck and c-src (IC50 = 5 µM) and also TNFα, IL-6, COX-1, COX-2. Also stimulates neural stem cell proliferation. Displays anti-inflammatory properties.
Solubility & Handling
Soluble in DMSO (25mM) or HCl (100mM, 1eq. HCl)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.