My Cart
My account
Menu
Main Menu

SB 203580

(HB1302)
Be the first to add a publication
Technical documents: SDS Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name SB 203580
Purity >98%
Description Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4) Frequently bought together
Write Your Own Review
You're reviewing:SB 203580
Rate this item:

Biological Data

Biological description Potent and selective p38 MAPK inhibitor (IC50 values are 32.6 and 22.4 nM for active and inactive forms of p38 respectively). Exhibits higher selectivity for p38α over p38β (IC50 values are 50 and 500 nM respectively). Inhibits many kinases including tyrosine kinases p56 lck and c-src (IC50 = 5 µM) and also TNFα, IL-6, COX-1, COX-2. Also stimulates neural stem cell proliferation. Displays anti-inflammatory properties.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (25mM) or HCl (100mM, 1eq. HCl)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
Molecular Weight 377.44
Chemical structure SB 203580 [152121-47-6] Chemical Structure
Molecular Formula C21H16FN3OS
CAS Number 152121-47-6
PubChem identifier 176155
SMILES CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
InChiKey CDMGBJANTYXAIV-UHFFFAOYSA-N

References for SB 203580

References are publications that support the biological activity of the product

  • Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle.

    Munoz L et al (2010) Eur J Pharmacol 635(1-3) : 212-8.
    Read more (PubMedID: 20226180)

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    Read more (PubMedID: 10998351)

  • RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

    Wadsworth SA et al (1999) J Pharmacol Exp Ther 291(2) : 680-7.
    Read more (PubMedID: 10525088)

  • Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase.

    Börsch-Haubold AG et al (1998) J Biol Chem 273(44) : 28766-72.
    Read more (PubMedID: 9786874)

4 Item(s)

Related Products
Grouped product items
Order: HB1302
Pack PriceQty
500μg
$47
1mg
$85
10mg
$191
50mg
$703
Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

Pexidartinib (PLX3397)
HB8991

Potent CSF-1R inhibitor. Widely used microglia-depletion agent.

Related Products

DAPT
Code:
HB3345
Pack:
5mg, 10mg, 25mg, 50mg, 10mM (1mL in DMSO)
Price:
$103, $175, $436, $733, $114
(Free trial)
γ-secretase inhibitor and classical notch inhibitor. Induces neuronal d...
ROCK inhibitor Y-27632
Code:
HB2297
Pack:
1mg, 2mg, 5mg, 10mg, 5x10mg, 25mg, 50mg, 10mM solution (in 1mL DMSO), 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$46, $72, $124, $175, $786, $339, $588, $180, $426, $710
(Free trial)

Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

SB 431542
Code:
HB3555
Pack:
1mg, 5mg, 2x5mg, 10mg, 25mg, 50mg, 10mM (1mL in DMSO)
Price:
$114, $160, $250, $243, $530, $1.000, $161
(Free trial)
Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation...