Potent and selective p38 MAPK inhibitor (IC50 values are 32.6 and 22.4 nM for active and inactive forms of p38 respectively). Exhibits higher selectivity for p38α over p38β (IC50 values are 50 and 500 nM respectively). Inhibits many kinases including tyrosine kinases p56 lck and c-src (IC50 = 5 µM) and also TNFα, IL-6, COX-1, COX-2. Also stimulates neural stem cell proliferation. Displays anti-inflammatory properties.
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in DMSO (25mM) or HCl (100mM, 1eq. HCl)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![SB 203580 [152121-47-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1302.png "SB 203580 [152121-47-6]")
Understanding purity and quality - a guide for life scientists
