SC 66

(HB1252)
Technical documents: SDS Datasheet

Product overview

Name SC 66
Description Akt inhibitor
Purity >98%
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Good. Happy with the product Verified customer, University of Brighton

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Biological Data

Biological description Akt (PKB) inhibitor. Binds at an allosteric site. Interferes with PH domain-PIP3 binding and enhances Akt ubiquitination. Blocks mTORC1/2, decreases glucose uptake and cell viability. Shows anti-tumor actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (75mM) or ethanol (75mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Molecular Weight 276.33
Chemical structure SC 66  [871361-88-5] Chemical Structure
Molecular Formula C18H16N2O
CAS Number 871361-88-5
PubChem identifier 6018993
SMILES O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1
InChiKey CYVVJSKZRBZHAV-UNZYHPAISA-N

References for SC 66

References are publications that support the biological activity of the product
  • AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

    Rashmi R et al (2014) PLoS One 9(4) : e92948.
  • Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.

    Jo H et al (2011) Proc Natl Acad Sci U S A 108(16) : 6486-91.