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SC 66

(HB1252)
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Technical documents: SDS Datasheet
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Product overview

Name SC 66
Purity >98%
Customer comments

Good. Happy with the product Verified customer, University of Brighton

Description Akt inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (2) Frequently bought together
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Biological Data

Biological description Akt (PKB) inhibitor. Binds at an allosteric site. Interferes with PH domain-PIP3 binding and enhances Akt ubiquitination. Blocks mTORC1/2, decreases glucose uptake and cell viability. Shows anti-tumor actions.

Solubility & Handling

Solubility overview Soluble in DMSO (75mM) or ethanol (75mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Molecular Weight 276.33
Chemical structure SC 66 [871361-88-5] Chemical Structure
Molecular Formula C18H16N2O
CAS Number 871361-88-5
PubChem identifier 6018993
SMILES O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1
InChiKey CYVVJSKZRBZHAV-UNZYHPAISA-N

References for SC 66

References are publications that support the biological activity of the product

  • AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

    Rashmi R et al (2014) PLoS One 9(4) : e92948.
    Read more (PubMedID: 24705275)

  • Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.

    Jo H et al (2011) Proc Natl Acad Sci U S A 108(16) : 6486-91.
    Read more (PubMedID: 21464312)

2 Item(s)

Grouped product items
Order: HB1252
Pack PriceQty
5mg
$58
10mg
$92
25mg
$188
Akt inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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