Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.
Potent ATP competitive p38 MAPK inhibitor (IC50 values are 50 and 100 nM for p38α and p38β respectively).
It inhibits TNF, IL-1 and CK1 (approx IC50 = 0.6 μM) and therefore inhibits CREB phosphorylation. It exhibits little or no activity at CK2.
It displays anti-inflammatory properties and induces apoptosis.
It can also be used as a 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids.
Also promotes stability of human pluripotent stem cells.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.
![SB 202190 [152121-30-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1301.png "SB 202190 [152121-30-7]")
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