Selective MEK1 and MEK2 inhibitor (IC50 values are 0.18 and 0.22 µM for MEK1 and MEK2 respectively) which allows selective inhibition of ERK activation. Blocks long term potentiation (LTP) in hippocampal slices in rat CA1. Also disrupts learning and memory and exhibits neuroprotective properties. Blood brain barrier permeable and active in vivo.
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in DMSO (100 mM) and in ethanol (50 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
Wang X et al (2003) J Pharmacol Exp Ther 304(1) : 172-8.