Selective MEK1 and MEK2 inhibitor (IC50 values are 0.18 and 0.22 µM for MEK1 and MEK2 respectively) which allows selective inhibition of ERK activation. Blocks long term potentiation (LTP) in hippocampal slices in rat CA1. Also disrupts learning and memory and exhibits neuroprotective properties. Blood brain barrier permeable and active in vivo.
Solubility & Handling
Soluble in DMSO (100 mM) and in ethanol (50 mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.