Product overview

Name SL327
Alternative names SL 327
Purity >98%
Description Selective MEK1 and MEK2 inhibitor
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Biological Data

Biological description Selective MEK1 and MEK2 inhibitor (IC50 values are 0.18 and 0.22 µM for MEK1 and MEK2 respectively) which allows selective inhibition of ERK activation. Blocks long term potentiation (LTP) in hippocampal slices in rat CA1. Also disrupts learning and memory and exhibits neuroprotective properties. Blood brain barrier permeable and active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100 mM) and in ethanol (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Molecular Weight 335.35
Chemical structure SL327  [305350-87-2] Chemical Structure
Molecular Formula C16H12F3N3S
CAS Number 305350-87-2
PubChem identifier 9549284
SMILES C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
Source Synthetic
InChi InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
MDL number MFCD06411432
Appearance White solid

References for SL327

References are publications that support the biological activity of the product
  • Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.

    Wang X et al (2003) J Pharmacol Exp Ther 304(1) : 172-8.
  • Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.

    Scherle PA et al (2000) J Biol Chem 275(47) : 37086-92.
  • A necessity for MAP kinase activation in mammalian spatial learning.

    Selcher JC et al (1999) Learn Mem 6(5) : 478-90.

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