Cytokine Storm / Immune response signaling
Cytokine storm describes an excessive immune response to external stimuli with the release of a large amount of pro-inflammatory cytokines. Cytokine storms occur in a range of infections and non-infectious diseases including COVID-19. The cytokine storm involves a variety of immune-related molecules such as interferon, interleukins, chemokines, CSFs and TNF-α. Increase in proinflammatory cytokines results in an influx of immune cells such as macrophages, T-Cells and neutrophils. The immune response to SARS-CoV2 infection also involves various signaling pathways. Researchers can save up to 50% on small molecules that affect cytokine storm and the immune response, as they are up to half the price of other suppliers.
View products: Angiotensin related | Cytokines, chemokines & NF-κB/I-κB | Inflammasomes | JAK/STAT | MAPK Signaling | PI3K/Akt/mTOR | Protease-Activated Receptors | TLR signaling
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XAV 939 (HB0660)
Description:Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.
Purity:>98%
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ROCK inhibitor Y-27632 (HB2297)
Description:Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Purity:>99%
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YM-254890 (HB6283)
Description:Potent Gq/11 signaling inhibitor. Reported as Gq- G-protein inhibitor and broad-spectrum inhibitor for Gq- and Gs-proteins.
Purity:>98%
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YM 298198 hydrochloride (HB0664)
Description:Potent, selective, non-competitive mGlu1 antagonist
Purity:>99%
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Zacopride hydrochloride (HB1694)
Description:Potent 5-HT3 antagonist and 5-HT4 agonist. Also selective IK1 channel agonist.
Purity:>99%
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Zatebradine hydrochloride (HB1151)
Description:HCN channel blocker. Potent, selective bradycardic agent.
Purity:>95%
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ZD 7288 (HB1152)
Description:HCN channel blocker. Modulates sino-atrial node function.
Purity:>98%
