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ZD 7288

Technical documents: SDS CoA Datasheet

Product overview

Name ZD 7288
Alternative names ICI D7288
Purity >98%
Customer comments

Works great. I used this compound for some time. It works great! Verified customer, Karolinska Institutet

Description HCN channel blocker. Modulates sino-atrial node function.
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ZD 7288 product vial image | Hello Bio

Biological Data

Biological description

Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).

Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.

Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).

Blocks long term potentiation (LTP) induction and displays anxiolytic properties.

Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Molecular Weight 292.81
Chemical structure ZD 7288  [133059-99-1] Chemical Structure
Molecular Formula C15H21ClN4
CAS Number 133059-99-1
PubChem identifier 123983
Source Synthetic
InChi InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
MDL number MFCD16879001
Appearance White solid

References for ZD 7288

References are publications that support the biological activity of the product
  • ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.

    Omelyanenko et al (2016) Springerplus 16 : 5:41
  • Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.

    Yeung M et al (2013) Hippocampus 23(4) : 278-86.
  • Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

    Wu X et al (2012) Channels (Austin) 6(6) : 438-42.
  • Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.

    BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.

4 Item(s)

These publications cite the use of ZD 7288 purchased from Hello Bio:
  • Morpho-electric diversity of human hippocampal CA1 pyramidal neurons.

    Mertens EJ et al (2024) Cell reports 43 : 114100
    PubMedID: 38607921
  • Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning

    Fieblinger T et al (2022) EMBO Rep 23(8) : e54361
    PubMedID: 35735260
  • Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

    Goldberg et al (2021) bioRxiv https://doi.org/10.1101/2021.11.29.470423 : doi
  • Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons

    D'Addario SL et al (2021) Neurobiol Stress 14 : 100324
    PubMedID: 33937445
  • GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation

    Lippiello P et al (2020) Cerebellum 19(6) : 751-761
    PubMedID: 32617840

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