Product overview
| Name | ZD 7288 |
| Description | HCN channel blocker. Modulates sino-atrial node function. |
| Alternative names | ICI D7288 |
| Purity | >98% |
| Customer comments | Works great. I used this compound for some time. It works great! Verified customer, Karolinska Institutet |
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Biological Data
| Biological description | Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM). Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons. Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM). Blocks long term potentiation (LTP) induction and displays anxiolytic properties. Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in water (100mM) or DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride |
| Molecular Weight | 292.81 |
| Chemical structure | ![ZD 7288 [133059-99-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1152.png "ZD 7288 [133059-99-1]") |
| Molecular Formula | C15H21ClN4 |
| CAS Number | 133059-99-1 |
| PubChem identifier | 123983 |
| SMILES | CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl |
| Source | Synthetic |
| InChi | InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H |
| InChiKey | DUWKUHWHTPRMAP-UHFFFAOYSA-N |
| MDL number | MFCD16879001 |
| Appearance | White solid |
References for ZD 7288
References are publications that support the biological activity of the product
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ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.
Omelyanenko et al (2016) Springerplus 16 : 5:41 -
Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.
Yeung M et al (2013) Hippocampus 23(4) : 278-86. -
Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?
Wu X et al (2012) Channels (Austin) 6(6) : 438-42. -
Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.
Publications
These publications cite the use of ZD 7288 purchased from Hello Bio:
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Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide
Hill et al (2020) eNeuro : doi: 10.1523/ENEURO.0330-20.2020PubMedID: 33229413 -
Ke Action in the In Vitro Cortical Slice Is Mitigated by Potassium Channel Blockade.
Voss et al (2018) Anesthesiology doi: 10.1097 : /ALN.0000000000002147.PubMedID: 29509582 -
Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.
Kurowski et al (2018) Front Cell Neurosci. : 12:93PubMedID: 29740284 -
Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels.
Grzelka et al (2017) Front Cell Neurosci. 11:341 : 2PubMedID: 29209170
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