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ZD 7288

Name: ZD 7288
Brand: Hello Bio
SKU: HB1152
Price: 122 USD
Availability: InStock
Rating: 100 (4 reviews)

(HB1152)

Publications (8)

Technical documents: SDS CoA Datasheet

Product overview

Name

ZD 7288

Alternative names

ICI D7288

Purity

>98%

Customer comments

Works great. I used this compound for some time. It works great! Verified customer, Karolinska Institutet

Description

HCN channel blocker. Modulates sino-atrial node function.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (4) Publications (8) References (4) Frequently bought together

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Biological Data

Biological description

Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC₅₀ = 15.0 µM).

Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current I_f and inhibits I_h in central neurons.

Also inhibits Na⁺ currents in dorsal root ganglion neurons (IC₅₀ = 1.17 µM).

Blocks long term potentiation (LTP) induction and displays anxiolytic properties.

Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo.

Solubility & Handling

Storage instructions

+4°C (desiccate)

Solubility overview

Soluble in water (100mM) or DMSO (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride

Molecular Weight

292.81

Chemical structure

Molecular Formula

C₁₅H₂₁ClN₄

CAS Number

133059-99-1

PubChem identifier

123983

SMILES

CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl

Source

Synthetic

InChi

InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H

InChiKey

DUWKUHWHTPRMAP-UHFFFAOYSA-N

MDL number

MFCD16879001

Appearance

White solid

References for ZD 7288

References are publications that support the biological activity of the product

ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.
Omelyanenko et al (2016) Springerplus 16 : 5:41
Read more (PubMedID: 26835223)
Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.
Yeung M et al (2013) Hippocampus 23(4) : 278-86.
Read more (PubMedID: 23280856)
Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?
Wu X et al (2012) Channels (Austin) 6(6) : 438-42.
Read more (PubMedID: 22989944)
Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.
Read more (PubMedID: 7693281)

Publications

Submit Yours Now

These publications cite the use of ZD 7288 purchased from Hello Bio:

Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning
Fieblinger T et al (2022) EMBO Rep 23(8) : e54361
PubMedID: 35735260
Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
Goldberg et al (2021) bioRxiv https://doi.org/10.1101/2021.11.29.470423 : doi
Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of I_h current in VTA dopaminergic neurons
D'Addario SL et al (2021) Neurobiol Stress 14 : 100324
PubMedID: 33937445
GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation
Lippiello P et al (2020) Cerebellum 19(6) : 751-761
PubMedID: 32617840
Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide
Hill et al (2020) eNeuro : doi: 10.1523/ENEURO.0330-20.2020
PubMedID: 33229413

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

HCN channel blocker. Modulates sino-atrial node function.

Order: HB1152
Pack	Price	Qty
10mg	$122
50mg	$505

ZD 7288

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

References for ZD 7288

ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.

Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.

Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.

Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning

Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of I_h current in VTA dopaminergic neurons

GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation

Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide

Technical guides

About you

Tell us about your publication!

ZD 7288

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

References for ZD 7288

ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.

Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.

Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.

Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning

Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons

GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation

Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide

Technical guides

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Tell us about your publication!

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Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of I_h current in VTA dopaminergic neurons