ZD 7288

(HB1152)
Technical documents: SDS CoA Datasheet

Product overview

Name ZD 7288
Description HCN channel blocker. Modulates sino-atrial node function.
Alternative names ICI D7288
Purity >98%
Customer comments

Works great. I used this compound for some time. It works great! Verified customer, Karolinska Institutet

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Biological Data

Biological description

Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).

Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.

Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).

Blocks long term potentiation (LTP) induction and displays anxiolytic properties.

Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Molecular Weight 292.81
Chemical structure ZD 7288  [133059-99-1] Chemical Structure
Molecular Formula C15H21ClN4
CAS Number 133059-99-1
PubChem identifier 123983
SMILES CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
Source Synthetic
InChi InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChiKey DUWKUHWHTPRMAP-UHFFFAOYSA-N
MDL number MFCD16879001
Appearance White solid

References for ZD 7288

References are publications that support the biological activity of the product
  • ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.

    Omelyanenko et al (2016) Springerplus 16 : 5:41
  • Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.

    Yeung M et al (2013) Hippocampus 23(4) : 278-86.
  • Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

    Wu X et al (2012) Channels (Austin) 6(6) : 438-42.
  • Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.

    BoSmith RE et al (1993) Br J Pharmacol 110(1) : 343-9.
Publications
These publications cite the use of ZD 7288 purchased from Hello Bio:
  • Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide

    Hill et al (2020) eNeuro : doi: 10.1523/ENEURO.0330-20.2020
    PubMedID: 33229413
  • Ke Action in the In Vitro Cortical Slice Is Mitigated by Potassium Channel Blockade.

    Voss et al (2018) Anesthesiology doi: 10.1097 : /ALN.0000000000002147.
    PubMedID: 29509582
  • Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.

    Kurowski et al (2018) Front Cell Neurosci. : 12:93
    PubMedID: 29740284
  • Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels.

    Grzelka et al (2017) Front Cell Neurosci. 11:341 : 2
    PubMedID: 29209170

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