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Zatebradine hydrochloride

(HB1151)
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Product overview

Name Zatebradine hydrochloride
Alternative names UL-FS 49
Purity >95%
Description HCN channel blocker. Potent, selective bradycardic agent.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 1.96 µM). Potent and selective bradycardic agent that acts at sinoatrial node. Also blocks voltage-gated outward K+ currents (IK) and hyperpolarization-activated inward currents (I(f)). Exhibits little or no activity for L-type Ca2+ currents (ICa). Displays antiarrythmic properties.

Solubility & Handling

Solubility overview Soluble in water (100mM)
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl ]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Molecular Weight 493.04
Chemical structure Zatebradine hydrochloride [91940-87-3] Chemical Structure
Molecular Formula C26H36N2O5.HCl
CAS Number 91940-87-3
PubChem identifier 3045335
SMILES Cl.COC1=CC=C(CCN(C)CCCN2CCC3=C(CC2=O)C=C(OC)C(OC)=C3)C=C1OC
InChi InChI=1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
InChiKey ZRNKXJHEQKMWCH-UHFFFAOYSA-N
MDL number MFCD06798356

References for Zatebradine hydrochloride

References are publications that support the biological activity of the product

  • Three different bradycardic agents, zatebradine, diltiazem and propranolol, distinctly modify heart rate variability and QT-interval variability.

    Yamabe M et al (2007) Pharmacology 80(4) : 293-303.
    Read more (PubMedID: 17690562)

  • Bradycardic and proarrhythmic properties of sinus node inhibitors.

    Stieber J et al (2006) Mol Pharmacol 69(4) : 1328-37.
    Read more (PubMedID: 16387796)

  • Acute effects of zatebradine on cardiac conduction and repolarization.

    Sen L et al (2002) J Cardiovasc Pharmacol Ther 7(1) : 29-38.
    Read more (PubMedID: 12000976)

  • Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptors.

    Satoh TO et al (2002) Pflugers Arch 443(4) : 532-40.
    Read more (PubMedID: 11907819)

4 Item(s)

Grouped product items
Order: HB1151
Pack PriceQty
5mg
$117
10mg
$197
25mg
$432
50mg
$803
HCN channel blocker. Potent, selective bradycardic agent.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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