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Biological Data
| Biological description | Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 1.96 µM). Potent and selective bradycardic agent that acts at sinoatrial node. Also blocks voltage-gated outward K+ currents (IK) and hyperpolarization-activated inward currents (I(f)). Exhibits little or no activity for L-type Ca2+ currents (ICa). Displays antiarrythmic properties. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl ]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride |
| Chemical structure | ![Zatebradine hydrochloride [91940-87-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Zatebradine hydrochloride [91940-87-3]") |
| Molecular Formula | C26H36N2O5.HCl |
| PubChem identifier | 3045335 |
| SMILES | Cl.COC1=CC=C(CCN(C)CCCN2CCC3=C(CC2=O)C=C(OC)C(OC)=C3)C=C1OC |
| InChi | InChI=1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H |
| InChiKey | ZRNKXJHEQKMWCH-UHFFFAOYSA-N |
References for Zatebradine hydrochloride
References are publications that support the biological activity of the product
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Three different bradycardic agents, zatebradine, diltiazem and propranolol, distinctly modify heart rate variability and QT-interval variability.
Yamabe M et al (2007) Pharmacology 80(4) : 293-303. -
Bradycardic and proarrhythmic properties of sinus node inhibitors.
Stieber J et al (2006) Mol Pharmacol 69(4) : 1328-37. -
Acute effects of zatebradine on cardiac conduction and repolarization.
Sen L et al (2002) J Cardiovasc Pharmacol Ther 7(1) : 29-38. -
Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptors.
Satoh TO et al (2002) Pflugers Arch 443(4) : 532-40.
HCN channel blocker. Potent, selective bradycardic agent.
![Zatebradine hydrochloride [91940-87-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1151.png "Zatebradine hydrochloride [91940-87-3]")
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