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Biological Data Biological description LDN193189 hydrochloride is a potent and selective ALK2/ALK3 inhibitor (IC50 values are 5 and 30 nM) which inhibits BMP4-mediated Smad1/5/8 phosphorylation. It is a derivative of dorsomorphin .
It may be used as a component for brain organoid production.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (50 mM), and in DMSO (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride
Chemical structure
Molecular Formula C25 H22 N6 .HCl
PubChem identifier 91900717
SMILES N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl
InChi InChI=1S/C25H22N6.2ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;;/h1-10,15-17,26H,11-14H2;2*1H
InChiKey CMQXLLAILGGLRV-UHFFFAOYSA-N
References for LDN193189 hydrochloride (LDN) References are publications that support the biological activity of the product
Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. Horbelt et al (2015) J Biol Chem 290(6) : 3390-404 The specificities of small molecule inhibitors of the TGFß and BMP pathways. Vogt et al (2011) Cell Signal 23(11) : 1831-42 Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Boergermann et al (2010) Int J Biochem Cell Biol 42(11) : 1802-7
Publications
These publications cite the use of LDN193189 hydrochloride (LDN) purchased from Hello Bio:
Parkinson’s associated protein DJ-1 regulates intercellular communication via extracellular vesicles in oxidative stress. Page et al (2025) Cellular and Molecular Life Sciences https://www.researchsquare.com/article/rs-5669239/v1
In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk Salis et al (2022) Cardiff University : Thesis
Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.
![LDN 193189 hydrochloride [1435934-00-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb5624_3.png "LDN 193189 hydrochloride [1435934-00-1]")
Understanding purity and quality - a guide for life scientists
