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LDN193189 hydrochloride (LDN)

(HB5624)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name LDN193189 hydrochloride (LDN)
Alternative names LDN
Purity >98%
Description Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews Publications (1) References (3) Frequently bought together
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Biological Data

Biological description

LDN193189 hydrochloride is a potent and selective ALK2/ALK3 inhibitor (IC50 values are 5 and 30 nM) which inhibits BMP4-mediated Smad1/5/8 phosphorylation. It is a derivative of dorsomorphin.


LDN193189 is frequently used in stem cell research. It promotes differentiation of neural progenitor cells from hPSCs.

It may be used as a component for brain organoid production.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (50 mM), and in DMSO (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride
Molecular Weight 442.94
Chemical structure LDN 193189 hydrochloride [1435934-00-1] Chemical Structure
Molecular Formula C25H22N6.HCl
CAS Number 1435934-00-1
PubChem identifier 91900717
SMILES N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl
InChi InChI=1S/C25H22N6.2ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;;/h1-10,15-17,26H,11-14H2;2*1H
InChiKey CMQXLLAILGGLRV-UHFFFAOYSA-N
Appearance Orange solid

References for LDN193189 hydrochloride (LDN)

References are publications that support the biological activity of the product

  • Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

    Horbelt et al (2015) J Biol Chem 290(6) : 3390-404
    Read more (PubMedID: 25368322)

  • The specificities of small molecule inhibitors of the TGFß and BMP pathways.

    Vogt et al (2011) Cell Signal 23(11) : 1831-42
    Read more (PubMedID: 21740966)

  • Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

    Boergermann et al (2010) Int J Biochem Cell Biol 42(11) : 1802-7
    Read more (PubMedID: 20691279)

3 Item(s)

Publications
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These publications cite the use of LDN193189 hydrochloride (LDN) purchased from Hello Bio:

  • In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk

    Salis et al (2022) Cardiff University : Thesis

1 Item

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Grouped product items
Order: HB5624
Pack PriceQty
10mg
$176
50mg
$635
Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.
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