Potent, selective, cell-permeable and irreversible proteasome inhibitor. Thought to irreversibly bind the active site N-terminal threonine residue of the 20S proteasome catalytic β-subunit to inhibit chymotrypsin and trypsin-like activities and block proteasome activity. Shows anticancer and anti-adipogenic activity, induces neuritogenesis, apoptosis and autophagy. Also inhibits NF-κB activation
Solubility & Handling
Solubility overview
Soluble in water, and in DMSO
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![Lactacystin [133343-34-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb3953.png "Lactacystin [133343-34-7]")
Understanding purity and quality - a guide for life scientists
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