Latrunculin A

Technical documents: SDS CoA Datasheet
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Product overview

Name Latrunculin A
Purity >96%
Description Actin polymerization inhibitor
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Biological Data

Biological description Actin polymerization inhibitor that binds to monomeric G actin (Kd = 0.2 µM). Also inhibits adenine nucleotide exchange on actin. Plays a role in depolymerization of tumor cell cytoskeleton and shows possible anti-inflammatory properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >96%
Chemical name 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo -2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17 -yl)-2-thiazolidinone
Molecular Weight 421.55
Chemical structure Latrunculin A [76343-93-6] Chemical Structure
Molecular Formula C22H31NO5S
CAS Number 76343-93-6
PubChem identifier 445420
SMILES C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(CC/C=C/C=C1)/C
InChi InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

References for Latrunculin A

References are publications that support the biological activity of the product
  • Characterization of the activities of actin-affecting drugs on tumor cell migration.

    Hayot C et al (2006) Toxicol Appl Pharmacol 211(1) : 30-40.
  • Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A.

    Yarmola EG et al (2000) J Biol Chem 275(36) : 28120-7.
  • Inhibition of actin polymerization by latrunculin A.

    Coué M et al (1987) FEBS Lett 213(2) : 316-8.

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