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Biological Data Biological description Potent EGF receptor tyrosine kinase (IC50 = 11 nM) and c-src (IC50 = 500 nM) inhibitor. Inhibits Ca2+ /calmodulin kinase II (IC50 = 200 nM). Blocks LTP induction.
Solubility & Handling Solubility overview Soluble in DMSO or methanol
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 5-((2,5-Dihydroxybenzyl)amino)-2-hydroxybenzoic acid
Chemical structure
Molecular Formula C14 H13 NO5
SMILES C1=CC(=C(C=C1NCC2=C(C=CC(=C2)O)O)C(=O)O)O
References for Lavendustin C References are publications that support the biological activity of the product
Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation. Schneider JC et al (2003) Am J Physiol Heart Circ Physiol 284(6) : H2311-9. Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation. Lindsay MA et al (1998) J Leukoc Biol 64(4) : 555-62. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. O'Dell TJ et al (1991) Nature 353(6344) : 558-60. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. Onoda T et al (1989) J Nat Prod 52(6) : 1252-7.
Potent EGFR tyrosine kinase inhibitor
![Lavendustin C [125697-93-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0376.png "Lavendustin C [125697-93-0]")
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