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Biological Data
| Biological description | Potent EGF receptor tyrosine kinase (IC50 = 11 nM) and c-src (IC50 = 500 nM) inhibitor. Inhibits Ca2+/calmodulin kinase II (IC50 = 200 nM). Blocks LTP induction. |
Solubility & Handling
| Solubility overview | Soluble in DMSO or methanol |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 5-((2,5-Dihydroxybenzyl)amino)-2-hydroxybenzoic acid |
| Chemical structure | ![Lavendustin C [125697-93-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Lavendustin C [125697-93-0]") |
| Molecular Formula | C14H13NO5 |
| SMILES | C1=CC(=C(C=C1NCC2=C(C=CC(=C2)O)O)C(=O)O)O |
References for Lavendustin C
References are publications that support the biological activity of the product
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Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation.
Schneider JC et al (2003) Am J Physiol Heart Circ Physiol 284(6) : H2311-9. -
Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation.
Lindsay MA et al (1998) J Leukoc Biol 64(4) : 555-62. -
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.
O'Dell TJ et al (1991) Nature 353(6344) : 558-60. -
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
Onoda T et al (1989) J Nat Prod 52(6) : 1252-7.
Potent EGFR tyrosine kinase inhibitor
![Lavendustin C [125697-93-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0376.png "Lavendustin C [125697-93-0]")
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