Product overview

Name Lamotrigine
Description Na2+ / K+ / Ca2+ channel inhibitor. Anticonvulsant.
Biological description Anticonvulsant. Inhibits voltage-dependent Na2+ channels, K+ and Ca2+ channels. Inhibits α4β2-nACh receptor mediated currents and reduces GABAA receptor transmission. Inhibits 5-HT, noradrenaline and dopamine uptake into synaptosomes (IC50 values are 474, 239 and 322 µM respectively). Shows anticonvulsant and anti-bipolar actions. Blood-brain barrier permeable.
Purity >99%
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Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (10mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Molecular Weight 256.09
Chemical structure Product image
Molecular Formula C9H7Cl2N5
CAS Number 84057-84-1
PubChem identifier 3878
SMILES NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl
InChiKey PYZRQGJRPPTADH-UHFFFAOYSA-N

References for Lamotrigine

References are publications that support the biological activity of the product
  • Modulation of calcium and potassium currents by lamotrigine.

    Grunze H et al (1998) Neuropsychobiology 38(3) : 131-8.
  • Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders.

    Braga MF et al (2002) Neuropharmacology 42(4) : 522-9.
  • Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.

    Southam E et al (1998) Eur J Pharmacol 358(1) : 19-24.
  • The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors.

    Zheng C et al (2010) J Pharmacol Exp Ther 335(2) : 401-8.