Anticonvulsant. Inhibits voltage-dependent Na2+ channels, K+ and Ca2+ channels. Inhibits α4β2-nACh receptor mediated currents and reduces GABAA receptor transmission. Inhibits 5-HT, noradrenaline and dopamine uptake into synaptosomes (IC50 values are 474, 239 and 322 µM respectively). Shows anticonvulsant and anti-bipolar actions. Blood-brain barrier permeable.
Solubility & Handling
Solubility overview
Soluble in ethanol (10mM) or DMSO (100mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders.
Braga MF et al (2002) Neuropharmacology 42(4) : 522-9.
These publications cite the use of Lamotrigine purchased from Hello Bio:
Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons
D'Addario SL et al (2021) Neurobiol Stress 14 : 100324
![Lamotrigine [84057-84-1] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0368.png "Lamotrigine [84057-84-1]")
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