The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Images Lamotrigine product vial image | Hello Bio
Lamotrigine product vial image | Hello Bio Biological Data Biological description Anticonvulsant. Inhibits voltage-dependent Na2+ channels, K+ and Ca2+ channels. Inhibits α4β2-nACh receptor mediated currents and reduces GABAA receptor transmission. Inhibits 5-HT, noradrenaline and dopamine uptake into synaptosomes (IC50 values are 474, 239 and 322 µM respectively). Shows anticonvulsant and anti-bipolar actions. Blood-brain barrier permeable.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in ethanol (10mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Chemical structure
Molecular Formula C9 H7 Cl2 N5
SMILES NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl
InChiKey PYZRQGJRPPTADH-UHFFFAOYSA-N
References for Lamotrigine References are publications that support the biological activity of the product
The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors. Zheng C et al (2010) J Pharmacol Exp Ther 335(2) : 401-8. Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders. Braga MF et al (2002) Neuropharmacology 42(4) : 522-9. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. Southam E et al (1998) Eur J Pharmacol 358(1) : 19-24. Modulation of calcium and potassium currents by lamotrigine. Grunze H et al (1998) Neuropsychobiology 38(3) : 131-8.
Publications
These publications cite the use of Lamotrigine purchased from Hello Bio:
Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons D'Addario SL et al (2021) Neurobiol Stress 14 : 100324
Na2+ / K+ / Ca2+ channel inhibitor. Anticonvulsant.
![Lamotrigine [84057-84-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0368.png "Lamotrigine [84057-84-1]")
Understanding purity and quality - a guide for life scientists
