Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
Kainic acid (HB0355)
Description:Prototypic, selective kainate receptor agonist. Potent excitant and neurotoxin.
Purity:>98%
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KB-R7943 mesylate (HB1133)
Description:Selective, reverse mode Na+ / Ca2+ exchange inhibitor
Purity:>99%
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KC 12291 hydrochloride (HB1019)
Description:Atypical voltage-gated sodium channel blocker
Purity:>97%
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KC159 (HB7601)
Description:Novel, selective Piezo1 channel activator. Improved efficacy and potency compared to Yoda1.
Purity:>98%
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Kenpaullone (HB1266)
Description:Potent CDK inhibitor. Also GSK-3 inhibitor. Generates iPSCs.
Purity:>98%
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KN-62 (HB0359)
Description:Selective CaM kinase II inhibitor. P2X7 receptor antagonist.
Purity:>98%
