Potent and non-selective tyrosine kinase inhibitor. Inhibits JAK2 and JAK3 (IC50 values are 0.9 and 3 nM respectively). Also inhibits TrkA, TrkB, TrkC and FLT3 and prevents phosphorylation of STAT5. Shows anti-proliferative and anti-tumor actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM) or ethanol (25mM)
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.
The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness.
Miknyoczki SJ et al (1999) Ann N Y Acad Sci 880 : 252-62.
![Lestaurtinib [111358-88-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1429.png "Lestaurtinib [111358-88-4]")
Understanding purity and quality - a guide for life scientists