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KC159

(HB7601)
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Product overview

Name KC159
Purity >98%
Description

Novel, selective Piezo1 channel activator. Improved efficacy and potency compared to Yoda1.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (1) Frequently bought together
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Biological Data

Biological description

Novel, selective Piezo1 channel activator which shows improved (or equivalent) reliability, efficacy and potency in functional assays compared to Yoda1 but is less potent than Yoda2 (KC289) (EC50 values are 280nM, 150nM and 600nM at mouse Piezo1 in calcium assays for KC159, Yoda2 (KC289) and Yoda1 respectively). Selective for Piezo1 over other membrane proteins and shows improved aqueous solubility compared to Yoda1. Active in vivo and shows vasorelaxant effects. Yoda1 analogue.

Solubility & Handling

Storage instructions Room Temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name

4-(5-{[(2,6-dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)benzoic acid

Molecular Weight 397.3
Chemical structure Chemical Structure
Molecular Formula C16H10Cl2N2O2S2
SMILES O=C(O)c1ccc(cc1)c1nnc(SCc2c(Cl)cccc2Cl)s1
Source Synthetic
InChi InChI=1S/C16H10Cl2N2O2S2/c17-12-2-1-3-13(18)11(12)8-23-16-20-19-14(24-16)9-4-6-10(7-5-9)15(21)22/h1-7H,8H2,(H,21,22)
InChiKey KFIUJWYVLYQUOY-UHFFFAOYSA-N

References for KC159

References are publications that support the biological activity of the product

  • Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.

    Parsonage G et al (2023) British journal of pharmacology 180 : 2039-2063
    Read more (PubMedID: 36457143)

1 Item

Grouped product items
Order: HB7601
Pack PriceQty
10mg
$156
50mg
$651

Novel, selective Piezo1 channel activator. Improved efficacy and potency compared to Yoda1.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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