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Images KN-62 product vial image | Hello Bio
KN-62 product vial image | Hello Bio Biological Data Biological description Selective CaM kinase II inhibitor (IC50 = 500 nM). Also potent, non-competitive P2X7 receptor antagonist (IC50 = 15 nM). Also inhibits GSK3β, PRAK and MAPKAP-K2. Cell-permeable, potential anticancer actions through suppression of HIF-1α.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-[(2S )-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester
Chemical structure
Molecular Formula C38 H35 N5 O6 S2
PubChem identifier 5312126
SMILES CN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
InChiKey RJVLFQBBRSMWHX-DHUJRADRSA-N
References for KN-62 References are publications that support the biological activity of the product
Specificity and mechanism of action of some commonly used protein kinase inhibitors. Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105. Effects of antagonists at the human recombinant P2X7 receptor. Chessell IP et al (1998) Br J Pharmacol 124(6) : 1314-20. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. Tokumitsu H et al (1990) J Biol Chem 265(8) : 4315-20.
Publications
These publications cite the use of KN-62 purchased from Hello Bio:
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus Park P et al (2021) Nat Commun 12(1) : 413
Selective CaM kinase II inhibitor. P2X7 receptor antagonist.
![KN-62 [127191-97-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0359a.png "KN-62 [127191-97-3]")
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