Selective CaM kinase II inhibitor (IC50 = 500 nM). Also potent, non-competitive P2X7 receptor antagonist (IC50 = 15 nM). Also inhibits GSK3β, PRAK and MAPKAP-K2. Cell-permeable, potential anticancer actions through suppression of HIF-1α.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Tokumitsu H et al (1990) J Biol Chem 265(8) : 4315-20.
![KN-62 [127191-97-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0359a.png "KN-62 [127191-97-3]")
Understanding purity and quality - a guide for life scientists
