Product overview

Name KB-R7943 mesylate
Purity >99%
Description Selective, reverse mode Na+ / Ca2+ exchange inhibitor
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Biological Data

Biological description Selective, reverse mode Na+/Ca2+ exchange inhibitor (IC50 = 0.7 µM). Also potent mitochondrial Ca2+ uniporter inhibitor (Ki = 5.5 µM). Does not affect Na+-dependent transport systems or ionotropic glutamate receptors. Decreases nitric oxide and hydoxyradical formation. Displays cardioprotective properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
Molecular Weight 427.49
Chemical structure KB-R7943 mesylate  [182004-65-5] Chemical Structure
Molecular Formula C16H17N3O3S.CH3SO3H
CAS Number 182004-65-5
PubChem identifier 9823846
SMILES CS(O)(=O)=O.NC(=N)SCCC1=CC=C(OCC2=CC=C(C=C2)[N+]([O-])=O)C=C1

References for KB-R7943 mesylate

References are publications that support the biological activity of the product
  • The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

    Santo-Domingo J et al (2007) Br J Pharmacol 151(5) : 647-54.
  • Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.

    Maczewski M et al (2003) Eur J Pharmacol 461(2-3) : 139-47.
  • Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

    Hoyt KR et al (1998) Mol Pharmacol 53(4) : 742-9.

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