KB-R7943 mesylate

Name: KB-R7943 mesylate
Brand: Hello Bio
SKU: HB1133
Price: 136 USD
Availability: InStock

(HB1133)

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Technical documents: SDS CoA Datasheet

Product overview

Name

KB-R7943 mesylate

Purity

>99%

Description

Selective, reverse mode Na⁺ / Ca²⁺ exchange inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3) Frequently bought together

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Biological Data

Biological description

Selective, reverse mode Na⁺/Ca²⁺ exchange inhibitor (IC₅₀ = 0.7 µM). Also potent mitochondrial Ca²⁺ uniporter inhibitor (K_i = 5.5 µM). Does not affect Na⁺-dependent transport systems or ionotropic glutamate receptors. Decreases nitric oxide and hydoxyradical formation. Displays cardioprotective properties.

Solubility & Handling

Storage instructions

Room temperature

Solubility overview

Soluble in DMSO (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate

Molecular Weight

427.49

Chemical structure

Molecular Formula

C₁₆H₁₇N₃O₃S.CH₃SO₃H

CAS Number

182004-65-5

PubChem identifier

9823846

SMILES

CS(O)(=O)=O.NC(=N)SCCC1=CC=C(OCC2=CC=C(C=C2)[N+]([O-])=O)C=C1

InChiKey

WGIKEBHIKKWJLG-UHFFFAOYSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for KB-R7943 mesylate

References are publications that support the biological activity of the product

The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.
Santo-Domingo J et al (2007) Br J Pharmacol 151(5) : 647-54.
Read more (PubMedID: 17471180)
Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.
Maczewski M et al (2003) Eur J Pharmacol 461(2-3) : 139-47.
Read more (PubMedID: 12586209)
Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
Hoyt KR et al (1998) Mol Pharmacol 53(4) : 742-9.
Read more (PubMedID: 9547366)

Selective, reverse mode Na⁺ / Ca²⁺ exchange inhibitor

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Order: HB1133
Pack	Price	Qty
10mg	$136
50mg	$524

KB-R7943 mesylate

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for KB-R7943 mesylate

The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.

Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

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KB-R7943 mesylate

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for KB-R7943 mesylate

The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.

Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area

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