Product overview

Name K252c
Alternative names Staurosporinone
Purity >99%
Description PKC inhibitor
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Biological Data

Biological description Protein kinase C (PKC) inhibitor with selectivity over protein kinase A (IC50 value = 214 nM at PKC). Inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 µM respectively). Inhibits human cytomegalovirus and amyloid β fibrillization. Shows cytotoxic and anti-tumor actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

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Chemical Data

Purity >99%
Chemical name 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Molecular Weight 311.34
Chemical structure K252c  [85753-43-1] Chemical Structure
Molecular Formula C20H13N3O
CAS Number 85753-43-1
PubChem identifier 3815
SMILES O=C(NC3)C1=C3C(C4=CC=CC=C4N5)=C5C2=C1C6=C(C=CC=C6)N2
InChiKey MEXUTNIFSHFQRG-UHFFFAOYSA-N

References for K252c

References are publications that support the biological activity of the product
  • Kinase inhibitors: not just for kinases anymore.

    McGovern SL et al (2003) J Med Chem 46(8) : 1478-83.
  • Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.

    Zimmermann A et al (2000) Antiviral Res 48(1) : 49-60.
  • Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.

    Fabre S et al (1993) Bioorg Med Chem 1(3) : 196-6.
  • K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

    Nakanishi S et al (1986) J Antibiot (Tokyo) 39(8) : 1066-71.

4 Item(s)