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K252c

(HB0353)
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Product overview

Name K252c
Alternative names Staurosporinone
Purity >99%
Description PKC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Protein kinase C (PKC) inhibitor with selectivity over protein kinase A (IC50 value = 214 nM at PKC). Inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 µM respectively). Inhibits human cytomegalovirus and amyloid β fibrillization. Shows cytotoxic and anti-tumor actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Molecular Weight 311.34
Chemical structure K252c [85753-43-1] Chemical Structure
Molecular Formula C20H13N3O
CAS Number 85753-43-1
PubChem identifier 3815
SMILES O=C(NC3)C1=C3C(C4=CC=CC=C4N5)=C5C2=C1C6=C(C=CC=C6)N2
InChiKey MEXUTNIFSHFQRG-UHFFFAOYSA-N

References for K252c

References are publications that support the biological activity of the product

  • Kinase inhibitors: not just for kinases anymore.

    McGovern SL et al (2003) J Med Chem 46(8) : 1478-83.
    Read more (PubMedID: 12672248)

  • Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.

    Zimmermann A et al (2000) Antiviral Res 48(1) : 49-60.
    Read more (PubMedID: 11080540)

  • Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.

    Fabre S et al (1993) Bioorg Med Chem 1(3) : 196-6.
    Read more (PubMedID: 8081852)

  • K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

    Nakanishi S et al (1986) J Antibiot (Tokyo) 39(8) : 1066-71.
    Read more (PubMedID: 3759658)

4 Item(s)

Grouped product items
Order: HB0353
Pack PriceQty
1mg
$131
PKC inhibitor
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Standard: $35

Hazardous: $35

Shipped on ice: $35

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