Product overview

Name Ketanserin tartrate
Description Selective 5-HT2 receptor antagonist
Alternative names R 41 468
Purity >97%
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Biological Data

Biological description Selective 5-HT2 serotonin receptor antagonist. Shows dose-dependent α-1 adrenoceptor inhibition. Used to differentiate between 5-HT1D subtypes by showing selectivity for 5-HT1Dα. Shows antihypertensive, antidepressant and anti-leishmaniasis actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview DMSO (100mM) and Water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
Molecular Weight 545.52
Chemical structure Ketanserin tartrate  [83846-83-7] Chemical Structure
Molecular Formula C22H22FN3O3.C4H6O6
CAS Number 83846-83-7
PubChem identifier 135348
SMILES OC(C(O)C(O)=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1
InChiKey KMTLTEVOQLMYRS-UHFFFAOYSA-N

References for Ketanserin tartrate

References are publications that support the biological activity of the product
  • Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani.

    Singh S et al (2014) Parasitol Res 113(6) : 2161-8.
  • Differences in the effects of ketanserin and GR127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.

    Razzaque Z et al (1995) Eur J Pharmacol 283(1-3) : 199-206.
  • Antihypertensive properties of ketanserin (R 41 468).

    Vanhoutte PM et al (1983) Fed Proc 42(2) : 182-5.

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