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Biological Data
| Biological description | Atypical voltage-gated sodium channel blocker. Reduces sustained Na+ channel current and inhibits peak current. Inhibits veratridine- and LPC-induced sustained sodium current contractures (IC50 values are 0.55 and 0.79 µM respectively). Shows cardioprotective, antiischemic and bradycardic actions. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in water (25mM) or DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride |
| Chemical structure | ![KC 12291 hydrochloride [181936-98-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "KC 12291 hydrochloride [181936-98-1]") |
| Molecular Formula | C22H27N3O3S.HCl |
| PubChem identifier | 22902387 |
| SMILES | CN(CCCOC2=NSC(C3=CC=CC=C3)=N2)CCC1=CC=C(OC)C(OC)=C1.Cl |
| InChiKey | KIJPRQYBNQKUAU-UHFFFAOYSA-N |
References for KC 12291 hydrochloride
References are publications that support the biological activity of the product
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Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
Létienne R et al (2006) Eur J Pharmacol 530(3) : 243-9. -
KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.
John GW et al (2004) Cardiovasc Drug Rev 22(1) : 17-26. -
Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.
Tamareille S et al (2002) J Cardiovasc Pharmacol 40(3) : 346-55.
Atypical voltage-gated sodium channel blocker
![KC 12291 hydrochloride [181936-98-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1019.png "KC 12291 hydrochloride [181936-98-1]")
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