Product overview

Name KC 12291 hydrochloride
Purity >97%
Description Atypical voltage-gated sodium channel blocker
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Biological Data

Biological description Atypical voltage-gated sodium channel blocker. Reduces sustained Na+ channel current and inhibits peak current. Inhibits veratridine- and LPC-induced sustained sodium current contractures (IC50 values are 0.55 and 0.79 µM respectively). Shows cardioprotective, antiischemic and bradycardic actions.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (25mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >97%
Chemical name 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
Molecular Weight 449.99
Chemical structure KC 12291 hydrochloride  [181936-98-1] Chemical Structure
Molecular Formula C22H27N3O3S.HCl
CAS Number 181936-98-1
PubChem identifier 22902387

References for KC 12291 hydrochloride

References are publications that support the biological activity of the product
  • Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.

    Létienne R et al (2006) Eur J Pharmacol 530(3) : 243-9.
  • KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.

    John GW et al (2004) Cardiovasc Drug Rev 22(1) : 17-26.
  • Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.

    Tamareille S et al (2002) J Cardiovasc Pharmacol 40(3) : 346-55.

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