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Biological Data Biological description Potent GABAB receptor agonist. Evokes hyperpolarizations in septal neurones (EC50 = 50 nM). Shows antidepressant actions. Blood-brain barrier permeable.
Solubility & Handling Solubility overview Soluble in water (100mM)
Storage instructions Room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3-Aminopropyl(methyl)phosphinic acid
Chemical structure
Molecular Formula C4 H12 NO2 P
InChiKey NHVRIDDXGZPJTJ-UHFFFAOYSA-N
References for SKF 97541 References are publications that support the biological activity of the product
Effects of GABAB receptor ligands in animal tests of depression and anxiety. Frankowska M et al (2007) Pharmacol Rep 59(6) : 645-55. Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro. Bon C et al (1996) Br J Pharmacol 118(4) : 961-7. Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices. Seabrook GR et al (1990) Br J Pharmacol 101(4) : 949-57.
Potent GABAB receptor agonist
![SKF 97541 [127729-35-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0954.png "SKF 97541 [127729-35-5]")
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