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Substance P

(HB2915)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Substance P
Biological description

Overview

Substance P is an 11 amino acid neuropeptide member of the tachykinin peptide family and is found in high quantities in the CNS. It preferentially activates the neurokinin-1 receptor (NK1R).

Uses and applications

It is secreted by neurons, acts as a neurotransmitter and is involved in many biological processes such as nociception and inflammation. It is also essential in gut motility.

Substance P also stimulates and modulates cytokine release in various cell types.

Alternative names SP
Purity >95%
Description Sensory neuropeptide
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (2) References (4) Frequently bought together
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (0.8 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name RPKPQQFFGLM (modifications: C-terminal amide)
Molecular Weight 1347.65
Chemical structure Substance P | [33507-63-0 ] Chemical Structure
Molecular Formula C63H98N18O13S
Sequence (one letter) RPKPQQFFGLM
Sequence (three letter) H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Modifications Met-11 = C-terminal amide
CAS Number 33507-63-0
PubChem identifier 36511
SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)N
InChiKey ADNPLDHMAVUMIW-CUZNLEPHSA-N
Protein length 11

References for Substance P

References are publications that support the biological activity of the product

  • Neuropeptide substance P and the immune response

    Mashaghi A et al (4249-4264) Cell Mol Life Sci Cell Mol Life Sci : 73(22)
    Species: 27314883 Read more (PubMedID: 2016)

  • Substance P and pain chronicity

    Zieglgänsberger W (2019) Cell Tissue Res 375(1) : 227-241
    Read more (PubMedID: 30284083)

  • Substance P and the Neurokinin-1 Receptor: The New CRF

    Schank JR et al (2017) Int Rev Neurobiol 136 : 151-175
    Read more (PubMedID: 29056150)

  • The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders

    Johnson MB et al (2016) Front Cell Neurosci 10 : 296
    Read more (PubMedID: 28101005)

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Order: HB2915
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1mg
$47
5mg
$121
Sensory neuropeptide
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