My Cart
My account
Menu
Main Menu

Substance P

(HB2915)
Be the first to add a publication
Technical documents: SDS CoA Datasheet
2  Reviews
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name Substance P
Biological description

Overview

Substance P is an 11 amino acid neuropeptide member of the tachykinin peptide family and is found in high quantities in the CNS. It preferentially activates the neurokinin-1 receptor (NK1R).

Uses and applications

It is secreted by neurons, acts as a neurotransmitter and is involved in many biological processes such as nociception and inflammation. It is also essential in gut motility.

Substance P also stimulates and modulates cytokine release in various cell types.

Alternative names SP
Purity >95%
Description Sensory neuropeptide
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (2) References (4) Frequently bought together
Write Your Own Review
You're reviewing:Substance P
Rate this item:

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (0.8 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
Chemical name RPKPQQFFGLM (modifications: C-terminal amide)
Molecular Weight 1347.65
Chemical structure Substance P | [33507-63-0 ] Chemical Structure
Molecular Formula C63H98N18O13S
Sequence (one letter) RPKPQQFFGLM
Sequence (three letter) H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Modifications Met-11 = C-terminal amide
CAS Number 33507-63-0
PubChem identifier 36511
SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)N
InChiKey ADNPLDHMAVUMIW-CUZNLEPHSA-N
Protein length 11

References for Substance P

References are publications that support the biological activity of the product

  • Neuropeptide substance P and the immune response

    Mashaghi A et al (4249-4264) Cell Mol Life Sci Cell Mol Life Sci : 73(22)
    Species: 27314883 Read more (PubMedID: 2016)

  • Substance P and pain chronicity

    Zieglgänsberger W (2019) Cell Tissue Res 375(1) : 227-241
    Read more (PubMedID: 30284083)

  • Substance P and the Neurokinin-1 Receptor: The New CRF

    Schank JR et al (2017) Int Rev Neurobiol 136 : 151-175
    Read more (PubMedID: 29056150)

  • The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders

    Johnson MB et al (2016) Front Cell Neurosci 10 : 296
    Read more (PubMedID: 28101005)

4 Item(s)

Related Products
Grouped product items
Order: HB2915
Pack PriceQty
1mg
$47
5mg
$121
Sensory neuropeptide
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

NBQX disodium salt
Code:
HB0443
Pack:
1mg, 10mg, 50mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$93, $193, $816, $460, $801
(Free trial)
Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
CNQX disodium salt
Code:
HB0205
Pack:
1mg, 10mg, 50mg, 10mM (add 1ml water), 20mM (add 1ml water)
Price:
$57, $112, $460, $61, $142
Potent, competitive AMPA / kainate receptor antagonist. Disodium salt.
D-AP5
Code:
HB0225
Pack:
1mg, 10mg, 50mg, 100mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$45, $116, $495, $685, $161, $289
(Free trial)

Selective, competitive NMDA receptor antagonist. Inhibits NMDAR-synaptic plasticity.