Substance P

(HB2915)
Technical documents: SDS CoA Datasheet
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Product overview

Name Substance P
Biological description

Overview

Substance P is an 11 amino acid neuropeptide member of the tachykinin peptide family and is found in high quantities in the CNS. It preferentially activates the neurokinin-1 receptor (NK1R).

Uses and applications

It is secreted by neurons, acts as a neurotransmitter and is involved in many biological processes such as nociception and inflammation. It is also essential in gut motility.

Substance P also stimulates and modulates cytokine release in various cell types.

Alternative names SP
Purity >95%
Description Sensory neuropeptide
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (0.8 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name RPKPQQFFGLM (modifications: C-terminal amide)
Molecular Weight 1347.65
Chemical structure Substance P | [33507-63-0 ] Chemical Structure
Molecular Formula C63H98N18O13S
Sequence (one letter) RPKPQQFFGLM
Sequence (three letter) H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Modifications Met-11 = C-terminal amide
CAS Number 33507-63-0
PubChem identifier 36511
SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)N
InChiKey ADNPLDHMAVUMIW-CUZNLEPHSA-N
Protein length 11

References for Substance P

References are publications that support the biological activity of the product
  • Neuropeptide substance P and the immune response

    Mashaghi A et al (4249-4264) Cell Mol Life Sci Cell Mol Life Sci : 73(22)
    Species: 27314883 Read more (PubMedID: 2016)
  • Substance P and pain chronicity

    Zieglgänsberger W (2019) Cell Tissue Res 375(1) : 227-241
  • Substance P and the Neurokinin-1 Receptor: The New CRF

    Schank JR et al (2017) Int Rev Neurobiol 136 : 151-175
  • The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders

    Johnson MB et al (2016) Front Cell Neurosci 10 : 296

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