Spiperone hydrochloride

(HB1656)

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Product overview

Name Spiperone hydrochloride
Purity >98%
Description Selective D2-like receptor antagonist. 5-HT2A antagonist.
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Biological Data

Biological description Selective D2-like receptor antagonist and 5-HT2A antagonist (Ki values are 0.06, 0.6, 0.08, 350 and 35000 at D2, D3, D4, D1 and D5 and 1.27 and >1000 nM at r5-HT2A and r5-HT2C receptors respectively). Also shows activity at 5-HT1A and 5-HT7 receptors. Shows antipsychotic effects. Active in vivo.

Solubility & Handling

Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
Molecular Weight 431.94
Chemical structure Spiperone hydrochloride  [2022-29-9] Chemical Structure
Molecular Formula C23H26FN3O2.HCl
CAS Number 2022-29-9
PubChem identifier 11957687
SMILES Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1
InChiKey QUIKMLCZZMOBLH-UHFFFAOYSA-N

References for Spiperone hydrochloride

References are publications that support the biological activity of the product
  • Neurotransmitters, Drugs and Brain Function

    Webster R (2001) Wiley :
  • Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high correlation with the profile for the human receptors.

    Aloyo VJ et al (2000) Eur J Pharmacol 406(2) : 163-9.
  • The D3 dopamine receptor: neurobiology and potential clinical relevance.

    Levant B (1997) Pharmacol Rev 49(3) : 231-52.

3 Item(s)