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Spiperone hydrochloride

(HB1656)
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Product overview

Name Spiperone hydrochloride
Purity >98%
Description Selective D2-like receptor antagonist. 5-HT2A antagonist.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Selective D2-like receptor antagonist and 5-HT2A antagonist (Ki values are 0.06, 0.6, 0.08, 350 and 35000 at D2, D3, D4, D1 and D5 and 1.27 and >1000 nM at r5-HT2A and r5-HT2C receptors respectively). Also shows activity at 5-HT1A and 5-HT7 receptors. Shows antipsychotic effects. Active in vivo.

Solubility & Handling

Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
Molecular Weight 431.94
Chemical structure Spiperone hydrochloride [2022-29-9] Chemical Structure
Molecular Formula C23H26FN3O2.HCl
CAS Number 2022-29-9
PubChem identifier 11957687
SMILES Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1
InChiKey QUIKMLCZZMOBLH-UHFFFAOYSA-N

References for Spiperone hydrochloride

References are publications that support the biological activity of the product

  • Neurotransmitters, Drugs and Brain Function

    Webster R (2001) Wiley :

  • Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high correlation with the profile for the human receptors.

    Aloyo VJ et al (2000) Eur J Pharmacol 406(2) : 163-9.
    Read more (PubMedID: 11020478)

  • The D3 dopamine receptor: neurobiology and potential clinical relevance.

    Levant B (1997) Pharmacol Rev 49(3) : 231-52.
    Read more (PubMedID: 9311022)

3 Item(s)

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Order: HB1656
Pack PriceQty
50mg
$133
Selective D2-like receptor antagonist. 5-HT2A antagonist.
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Standard: $35

Hazardous: $35

Shipped on ice: $35

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