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Go 6983

(HB0303)
Publications (2)
Technical documents: SDS Datasheet
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Product overview

Name Go 6983
Purity >98%
Description Broad spectrum PKC inhibitor. Optimizes naïve human pluripotent stem cell growth and viability
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews Publications (2) References (4) Frequently bought together
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Go 6983 product vial image | Hello Bio
Go 6983 product vial image | Hello Bio

Go 6983 product vial image | Hello Bio

Go 6983 product vial image | Hello Bio

Biological Data

Biological description Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 nM and 20 µM for PKC-α, PKC-β, PKC-γ, PKC-δ, PKC-ζ and PKC-µ respectively). Also suppresses TNF-α production (IC50 = 8.3 nM) and up-regulates Akt phosphorylation. Displays cardioprotective properties. Also optimizes naïve human pluripotent stem cell growth and viability.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Weight 442.51
Chemical structure Go 6983 [133053-19-7] Chemical Structure
Molecular Formula C26H26N4O3
CAS Number 133053-19-7
PubChem identifier 3499
SMILES CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
InChi InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChiKey LLJJDLHGZUOMQP-UHFFFAOYSA-N
MDL number MFCD04040031

References for Go 6983

References are publications that support the biological activity of the product

  • PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.

    Kim SY et al (2011) BMB Rep 44(2) : 140-5.
    Read more (PubMedID: 21345315)

  • Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.

    Young LH et al (2005) Cardiovasc Drug Rev 23(3) : 255-72.
    Read more (PubMedID: 16252018)

  • Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.

    Foey AD et al (2004) Immunology 112(1) : 44-53.
    Read more (PubMedID: 15096183)

  • Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.

    Gschwendt M et al (1996) FEBS Lett 392(2) : 77-80.
    Read more (PubMedID: 8772178)

4 Item(s)

Publications
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These publications cite the use of Go 6983 purchased from Hello Bio:

  • Oscillatory Deficits in the Sub-Chronic PCP Rat Model for Schizophrenia Are Reversed by mGlu5 Receptor-Positive Allosteric Modulators VU0409551 and VU0360172.

    Brown J et al (2023) Cells 12
    PubMedID: 36980260

  • Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves

    McMillan H et al (2021) FASEB J 35(5) : e21492
    PubMedID: 33788969

2 Item(s)

Grouped product items
Order: HB0303
Pack PriceQty
1mg
$32
5mg
$153
10mg
$230
Broad spectrum PKC inhibitor. Optimizes naïve human pluripotent stem cell growth and viability
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