Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. IWP 4 (HB3066)

    Description:

    Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $550
    Qty:
  2. JK 184 (HB3179)

    Description:

    Downstream Hedgehog signaling pathway inhibitor. Alcohol dehydrogenase 7 inhibitor.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $191
    Qty:
    Pack:
    50mg
    Price:
    $712
    Qty:
  3. Pack:
    10mg
    Price:
    $170
    Qty:
    Pack:
    25mg
    Price:
    $358
    Qty:
  4. Pack:
    50mg
    Price:
    $762
    Qty:
  5. KY 02111 (HB3465)

    Description:

    Wnt signaling inhibitor. Promotes differentiation of hESCs and iPSCs into cardiomyocytes.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $168
    Qty:
    Pack:
    50mg
    Price:
    $613
    Qty:
  6. Description:

    Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $184
    Qty:
    Pack:
    50mg
    Price:
    $662
    Qty:
  7. Pack:
    5mg
    Price:
    Qty:
    Pack:
    25mg
    Price:
    $184
    Qty:
  8. Pack:
    100mg
    Price:
    $69
    Qty:
    Pack:
    100mM (add 1ml water)
    Price:
    $43
    Qty:
  9. Description:

    Broad spectrum antibiotic. Potent microglial activation inhibitor. Allows formation of EPSs.

    Purity:

    >98%

    Pack:
    100mg
    Price:
    $65
    Qty:
    Pack:
    250mg
    Price:
    $109
    Qty:
    Pack:
    1g
    Price:
    $329
    Qty:
  10. Mitomycin C (HB4458)

    Description:

    Antibiotic. DNA synthesis inhibitor.

    Purity:

    >97%

    Pack:
    5mg
    Price:
    $77
    Qty:
    Pack:
    25mg
    Price:
    $299
    Qty:
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