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IBMX

(HB3000)
Publications (2)
Technical documents: SDS CoA Datasheet
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Product overview

Name IBMX
Purity >98%
Description Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews Publications (2) References (3) Frequently bought together
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Biological Data

Biological description Non-selective, competitive, cell permeable cAMP and cGMP PDE inhibitor, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor which increases cAMP levels. IBMX also enhances 3T3-L1 cell differentiation and promotes neural progenitor cell differentiation.

Solubility & Handling

Solubility overview Soluble in DMSO (75 mM), and in ethanol (50 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Molecular Weight 222.3
Chemical structure IBMX [28822-58-4] Chemical Structure
Molecular Formula C10H14N4O2
CAS Number 28822-58-4
PubChem identifier 3758
SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChi InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChiKey APIXJSLKIYYUKG-UHFFFAOYSA-N
MDL number MFCD00005584
Appearance White to off-white solid

References for IBMX

References are publications that support the biological activity of the product

  • cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.

    Lepski et al (2013) Front Cell Neurosci. 19 : 7:155
    Read more (PubMedID: 24065885)

  • Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine affects rabbit ovaries and oviduct.

    Sirotkin et al (2010) Eur J Pharmacol 643(1) : 145-51
    Read more (PubMedID: 20599929)

  • Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.

    Freitag et al (1998) Eur J Pharmacol 354(1) : 67-71
    Read more (PubMedID: 9726632)

3 Item(s)

Publications
Submit Yours Now
These publications cite the use of IBMX purchased from Hello Bio:

  • Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning

    Fieblinger T et al (2022) EMBO Rep 23(8) : e54361
    PubMedID: 35735260

  • PACmn for improved optogenetic control of intracellular cAMP

    Yang S et al (2021) BMC Biol 19(1) : 227
    PubMedID: 34663304

2 Item(s)

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Grouped product items
Order: HB3000
Pack PriceQty
100mg
$49
500mg
$138
Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

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