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Trans-ISRIB

(HB4567)
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Product overview

Name Trans-ISRIB
Purity >98%
Description

Integrated stress response (ISR) inhibitor. Promotes pluripotent stem cell survival as part of the CEPT cocktail.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

Suppresses the integrated stress response (ISR) within a defined window of activation which makes cells resistant to eIF2α phosphorylation effects (IC50 = 5 nM). Also enhances long-term memory in rodent models. Promotes pluripotent stem cell survival as part of the CEPT cocktail which improves differentiated cell survival following cryopreservation.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (10 mM with warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
Molecular Weight 451.34
Chemical structure 1597403-47-8 Chemical Structure
Molecular Formula C22H24Cl2N2O4
CAS Number 1597403-47-8
PubChem identifier 1011240
SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
InChi InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChiKey HJGMCDHQPXTGAV-UHFFFAOYSA-N

References for Trans-ISRIB

References are publications that support the biological activity of the product

  • ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

    Zyryanova AF et al (2021) Molecular cell 81 : 88-103.e6
    Read more (PubMedID: 33220178)

  • Small molecule ISRIB suppresses the integrated stress response within a defined window of activation.

    Rabouw HH et al (2019) Proceedings of the National Academy of Sciences of the United States of America 116 : 2097-2102
    Read more (PubMedID: 30674674)

  • The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

    Sidrauski C et al (2015) eLife 4 :
    Read more (PubMedID: 25719440)

3 Item(s)

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Order: HB4567
Pack PriceQty
10mg
$120
50mg
$415

Integrated stress response (ISR) inhibitor. Promotes pluripotent stem cell survival as part of the CEPT cocktail.

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Hazardous: $35

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